2,2-Dichloro-N-(9-oxo-9H-fluoren-4-yl)ethanimidic acid | 7145-72-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2,2-Dichloro-N-(9-oxo-9H-fluoren-4-yl)ethanimidic acid
• 英文别名: 2,2-dichloro-N-(9-oxofluoren-4-yl)acetamide
• CAS: 7145-72-4
• 化学式: C₁₅H₉Cl₂NO₂
• 分子量: 306.1
• InChiKey: UYIIWKLDGVUVRE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER
  申请人：British Columbia Cancer Agency Branch

  公开号：EP2819662B1

  公开（公告）日：2019-04-10
• US9552457B2
  申请人：——

  公开号：US9552457B2

  公开（公告）日：2017-01-24
• [EN] REPROGRAMMING EFFECTOR PROTEIN INTERACTIONS TO CORRECT EPIGENETIC DEFECTS IN CANCER<br/>[FR] REPROGRAMMATION D'INTERACTIONS ENTRE PROTÉINES EFFECTRICES POUR CORRIGER DES DÉFAUTS ÉPIGÉNÉTIQUES DANS LE CANCER
  申请人：BRITISH COLUMBIA CANCER AGENCY

  公开号：WO2013127011A1

  公开（公告）日：2013-09-06

  Methods of "reprogramming" epigenetic mark readers or erasers to recognize epigenetic marks other than their cognate (or natural) marks are provided. Reprogramming the reader or eraser can offset the effects of aberrant writer activity (for example, loss of function or overactivity) that can contribute to certain diseases states, such as cancer. The use of the reprogramming compounds identified by these methods in the treatment of such disease states is also provided. Exemplary mark readers that can be targeted by these methods include BPTF and CBX2.