2.9-Diamino-fluoren | 7148-37-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 2.9-Diamino-fluoren
• 英文别名: fluorene-2,9-diyldiamine；Fluoren-2,9-diyldiamin；Fluorene-2,9-diamine；9H-fluorene-2,9-diamine
• CAS: 7148-37-0
• 化学式: C₁₃H₁₂N₂
• 分子量: 196.252
• InChiKey: AKTKXGABFWDIPW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  15
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-<9-Isopropylidenamino-fluorenyl-(2)>-acetamid 在 盐酸 作用下， 生成 2.9-Diamino-fluoren
  参考文献：
  名称：

  ATTEMPTS TO RESOLVE DERIVATIVES OF FLUORENE. PARA-AMINOBENZOPHENONE HYDRAZONE¹

  摘要：

  DOI：

  10.1021/ja01371a066

文献信息

• Conjugated Thiophenes Having Conducting Properties and Synthesis of Same
  申请人：Skene G. William

  公开号：US20070287842A1

  公开（公告）日：2007-12-13

  The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favour of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.

  本发明涉及含有芳香硫吡咯核的共轭寡聚物和聚合物。这些共轭材料是通过芳香族二胺和芳香族二醛或具有同时含有醛和胺的双官能团芳香族基团的简单而有效的缩合反应获得的。在各种溶剂中，在从常温到沸点温度的温度范围内缩合互补的官能团，得到了可以随后铸造成薄膜的共轭寡聚物和聚合物。在温和的条件下进行寡聚和聚合，去除产生的水副产物，有利于使平衡向共轭产物方向移动。所得的共轭化合物可以通过掺杂制成导电材料，根据所选择的掺杂剂，可以得到p型或n型导体的电导材料。
• CONJUGATED THIOPHENES HAVING CONDUCTING PROPERTIES AND SYNTHESIS OF SAME
  申请人：Skene William G.

  公开号：US20120004386A1

  公开（公告）日：2012-01-05

  The present invention relates to conjugated oligomers and polymers comprising aromatic thiophene cores. The conjugated materials are obtained by simple and efficient condensation of an aryl diamine and an aryl dialdehyde or a bifunctional aryl moiety comprising both an aldehyde and an amine. Condensation of the complementary moieties at temperatures ranging from ambient to refluxing temperatures in various solvents resulted in conjugated oligomers and polymers that can subsequently be cast into thin films. Oligomerization and polymerization can be done under mild conditions with removal of the resulting water bi-product responsible for shifting the equilibrium in favour of the conjugated products. The resulting conjugated compounds can be made conducting with dopants affording electrically conducting materials of either p-type or n-type conductors depending on the dopant selected.

  本发明涉及含有芳香硫杂苯核的共轭寡聚物和聚合物。这些共轭材料是通过芳香族二胺和芳香族二醛或含有醛和胺的双官能团芳香族基团的简单高效缩合反应得到的。在各种溶剂中，将互补的官能团在环境温度到沸腾温度范围内缩合，得到共轭寡聚物和聚合物，随后可以将其铸造成薄膜。在温和的条件下进行寡聚和聚合反应，通过去除生成的水分子，使平衡向共轭产物倾斜。所得的共轭化合物可以通过掺杂剂使其导电，从而获得p型或n型导体的电导材料。
• Factor VIIa inhibitors
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1059302A1

  公开（公告）日：2000-12-13

  The present invention relates to compounds of the formula I, in which R1, R2, R91, R92, R93, R94, R95, R96, R97, r, s and t have the meanings indicated in the claims. The compounds of the formula I are valuable pharmacologically active compounds. They exhibit a strong antithrombotic effect and are suitable, for example, for the therapy and prophylaxis of thromboembolic diseases or restenoses. They are reversible inhibitors of the blood clotting enzyme factor VIIa and can in general be applied in conditions in which an undesired activity of factor VIIa is present or for the cure or prevention of which an inhibition of factor VIIa is intended. The invention furthermore relates to processes for the preparation of compounds of the formula I, their use, in particular as active ingredients in pharmaceuticals, and pharmaceutical preparations comprising them.

  本发明涉及式 I 的化合物、 其中 R1、R2、R91、R92、R93、R94、R95、R96、R97、r、s 和 t 具有权利要求中所述的含义。式 I 的化合物是具有重要药理活性的化合物。它们具有很强的抗血栓作用，适用于血栓栓塞性疾病或再狭窄的治疗和预防。它们是血液凝固酶 VIIa 因子的可逆抑制剂，一般可用于存在 VIIa 因子不良活性的情况，或用于治疗或预防 VIIa 因子的抑制。此外，本发明还涉及式 I 化合物的制备工艺、其用途（尤其是作为药物的活性成分）以及由其组成的药物制剂。
• Cardini, 1943, vol. 14, p. 20,24
  作者：Cardini

  DOI：——

  日期：——
• FACTOR VIIA INHIBITORS
  申请人：Aventis Pharma Deutschland GmbH

  公开号：EP1189929A2

  公开（公告）日：2002-03-27