N-[2-(2-Benzyloxy-7-methoxy-naphthalen-1-yl)-ethyl]-propionamide | 198470-50-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[2-(2-Benzyloxy-7-methoxy-naphthalen-1-yl)-ethyl]-propionamide
• 英文别名: N-[2-(7-methoxy-2-phenylmethoxynaphthalen-1-yl)ethyl]propanamide
• CAS: 198470-50-7
• 化学式: C₂₃H₂₅NO₃
• 分子量: 363.456
• InChiKey: VPIPDHUIJZFREX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  47.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-[2-(2-Benzyloxy-7-methoxy-naphthalen-1-yl)-ethyl]-propionamide 在 platinum(IV) oxide 氢气 、 碘 、 potassium carbonate 、 三苯基膦 作用下， 生成 N-{2-[2-(2-Dimethylamino-ethoxy)-7-methoxy-naphthalen-1-yl]-ethyl}-propionamide
  参考文献：
  名称：

  The development of a charged melatonin receptor ligand

  摘要：

  We report the synthesis and radioligand binding analysis of a novel charged melatonin receptor ligand, N-[2-(2-Trimethylammoniumethyleneoxy-7-methoxy)ethyl]propionamide iodide. The charged ligand has potential in determining whether internalization of the melatonin receptor occurs following melatonin exposure. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00444-7
• 作为产物：
  描述：

  7-甲氧基-2-萘 在 sodium hydroxide 、 lithium aluminium tetrahydride 、 ammonium acetate 、 potassium carbonate 作用下， 生成 N-[2-(2-Benzyloxy-7-methoxy-naphthalen-1-yl)-ethyl]-propionamide
  参考文献：
  名称：

  The development of a charged melatonin receptor ligand

  摘要：

  We report the synthesis and radioligand binding analysis of a novel charged melatonin receptor ligand, N-[2-(2-Trimethylammoniumethyleneoxy-7-methoxy)ethyl]propionamide iodide. The charged ligand has potential in determining whether internalization of the melatonin receptor occurs following melatonin exposure. (C) 1997 Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(97)00444-7

文献信息

• Development of a High-Affinity Ligand That Binds Irreversibly to Mel_1b Melatonin Receptors
  作者：Paula A. Witt-Enderby、Guo-Hua Chu、Megan L. Gillen、Pui-Kai Li

  DOI：10.1021/jm970437q

  日期：1997.12.1
• The development of a charged melatonin receptor ligand
  作者：Pui-Kai Li、Guo-Hua Chu、Megan L. Gillen、Tejal Parekh、Paula A. Witt-Enderby

  DOI：10.1016/s0960-894x(97)00444-7

  日期：1997.9

  We report the synthesis and radioligand binding analysis of a novel charged melatonin receptor ligand, N-[2-(2-Trimethylammoniumethyleneoxy-7-methoxy)ethyl]propionamide iodide. The charged ligand has potential in determining whether internalization of the melatonin receptor occurs following melatonin exposure. (C) 1997 Elsevier Science Ltd.