1-methoxy-3,8-dimethyl-9-xanthenone | 88521-85-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 1-methoxy-3,8-dimethyl-9-xanthenone
• 英文别名: 1-methoxy-3,8-dimethyl-xanthen-9-one；1-Methoxy-3,8-dimethyl-9H-xanthen-9-one；1-methoxy-3,8-dimethylxanthen-9-one
• CAS: 88521-85-1
• 化学式: C₁₆H₁₄O₃
• 分子量: 254.285
• InChiKey: VWIJENRXCZYAMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-甲氧基-6-甲基苯甲酰氯 在 mercury(II) diacetate 、 sodium acetate 、 四氯化锡 、 potassium carbonate 、 溶剂黄146 、 三乙胺 作用下， 以 二氯甲烷 、 丙酮 、 乙腈 为溶剂， 反应 10.0h， 生成 1-methoxy-3,8-dimethyl-9-xanthenone
  参考文献：
  名称：

  Synthetic studies towards the benzophenone precursor for balanol

  摘要：

  Synthesis of 4-carboxy-2,6-dimethoxyphenyl 2'-carboxy-6'-methoxyphenyl ketone, an important precursor for balanol's benzophenone portion, has been achieved via a short and efficient route in three steps using ortho-lithiation as the key step. In another approach aromatization of 2-(2'-methoxy-6'-methylbenzoyl)-5-methyl-1,3-cyclohexanedione afforded benzophenone precursor 2,6-dimethoxy-4-methylphenyl 2'-methoxy-6'-methylphenyl ketone along with the formation of substituted xanthone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2003.12.029

文献信息

• Oxidation of 9-Xanthenones with Lead(IV) Acetate. Formation of Di-γ-lactones
  作者：Hiroshi Nishino、Kazu Kurosawa

  DOI：10.1246/bcsj.56.2847

  日期：1983.9

  The oxidation of 9-xanthenones with lead(IV) acetate afforded 3a,3b,6a,12b-tetrahydro-2H-difuro[3,2-a:3′,2′-c]xanthene-2,5,7(3H,6H)-triones in addition to other products. Characterization of the di-γ-lactones and the difference between the oxidation reaction of lead(IV) and manganese(III) acetates in the 9-xanthenone system are discussed.

  用乙酸铅 (IV) 氧化 9-呫吨酮得到 3a,3b,6a,12b-四氢-2H-二呋喃 [3,2-a:3',2'-c]xanthene-2,5,7(3H ,6H)-triones 以及其他产品。讨论了二-γ-内酯的表征以及 9-呫吨酮系统中乙酸铅 (IV) 和乙酸锰 (III) 的氧化反应之间的差异。
• Synthetic studies towards the benzophenone precursor for balanol
  作者：Mahesh L Patil、Vishnu H Deshpande、S Ramlingam、Hanumant B Borate

  DOI：10.1016/j.tet.2003.12.029

  日期：2004.2

  Synthesis of 4-carboxy-2,6-dimethoxyphenyl 2'-carboxy-6'-methoxyphenyl ketone, an important precursor for balanol's benzophenone portion, has been achieved via a short and efficient route in three steps using ortho-lithiation as the key step. In another approach aromatization of 2-(2'-methoxy-6'-methylbenzoyl)-5-methyl-1,3-cyclohexanedione afforded benzophenone precursor 2,6-dimethoxy-4-methylphenyl 2'-methoxy-6'-methylphenyl ketone along with the formation of substituted xanthone. (C) 2003 Elsevier Ltd. All rights reserved.