(S)-5,5-dimethyl-4-phenyl-3-((S)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one | 1456506-34-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: (S)-5,5-dimethyl-4-phenyl-3-((S)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one
• 英文别名: (4S)-5,5-dimethyl-4-phenyl-3-[(1S)-4-(1-pyrimidin-2-ylpyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl]-1,3-oxazolidin-2-one
• CAS: 1456506-34-5
• 化学式: C₂₈H₂₇N₅O₂
• 分子量: 465.555
• InChiKey: JFUNKUOLBQSYFY-RDGATRHJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  35
• 可旋转键数：
  4
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  73.1
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  6-溴-4-氮杂吲哚 在 四(三苯基膦)钯 、 1,1'-双(二苯膦基)二茂铁二氯化钯(II)二氯甲烷复合物 、 potassium acetate 、 sodium carbonate 、 potassium carbonate 作用下， 以 1,4-二氧六环 、 乙腈 为溶剂， 反应 50.0h， 生成 (S)-5,5-dimethyl-4-phenyl-3-((S)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one 、 (S)-5,5-dimethyl-4-phenyl-3-((R)-4-(1-(pyrimidin-2-yl)-1H-pyrrolo[3,2-b]pyridin-6-yl)cyclohex-3-en-1-yl)oxazolidin-2-one
  参考文献：
  名称：

  [EN] OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF
  [FR] COMPOSÉS D'OXAZOLIDINONE ET LEURS DÉRIVÉS

  摘要：

  式(I)和式(II)的化合物是坦克酶的有用抑制剂。式(I)和式(II)的化合物具有以下结构：其中变量的定义在此提供。

  公开号：

  WO2013134079A1

文献信息

• OXAZOLIDINONE COMPOUNDS AND DERIVATIVES THEREOF
  申请人：AMGEN INC.

  公开号：US20150045368A1

  公开（公告）日：2015-02-12

  Compounds of Formula (I) and Formula (II) are useful inhibitors of tankyrase. Compounds of Formula (I) and Formula (II) have the following structure: where the definitions of the variables are provided herein.

  式(I)和式(II)的化合物是坦克酰酶的有用抑制剂。式(I)和式(II)的化合物具有以下结构：其中变量的定义在此提供。
• ENZYMATIC NANOSENSOR COMPOSITIONS AND METHODS
  申请人：Northeastern University

  公开号：EP2823051A2

  公开（公告）日：2015-01-14
• US9340549B2
  申请人：——

  公开号：US9340549B2

  公开（公告）日：2016-05-17
• [EN] ENZYMATIC NANOSENSOR COMPOSITIONS AND METHODS<br/>[FR] COMPOSITIONS DE NANOCAPTEUR ENZYMATIQUE ET PROCÉDÉS
  申请人：UNIV NORTHEASTERN

  公开号：WO2013134401A2

  公开（公告）日：2013-09-12

  Disclosed herein are compositions including a nanosensor that is sensitive to an analyte such that the nanosensor emits a fluorescent signal upon detecting the analyte, and a catalytic agent that catalyzes a reaction in which a target substrate is converted into one or more products, such that at least one of the one or more products is the analyte. In addition, methods of using the nanosensor-catalytic agent compositions to detect a target substrate are disclosed.
• [EN] DIGITAL ASSAY FOR QUANTIFYING AND CONCENTRATING ANALYTES<br/>[FR] DOSAGE BIOLOGIQUE NUMÉRIQUE POUR QUANTIFIER ET CONCENTRER DES ANALYTES
  申请人：CALIFORNIA INST OF TECHN

  公开号：WO2015009967A1

  公开（公告）日：2015-01-22

  Provided herein are methods, compositions, and devices for the identification and quantification of analytes, such as nucleic acids, proteins, cells or other biological samples. The methods, compositions, and devices are suited for accurate, portable analysis of small amounts of analyte.