N-phenyl-leucine nitrile | 100253-25-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-phenyl-leucine nitrile
• 英文别名: N-Phenyl-leucin-nitril；α-Anilino-isocapronsaeure-nitril；(α-Cyan-isoamyl)-anilin；2-Anilino-4-methylpentanenitrile
• CAS: 100253-25-6
• 化学式: C₁₂H₁₆N₂
• 分子量: 188.272
• InChiKey: WZHVGDVFNLKLCZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  35.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  氢氰酸 、 N-(isoamylidene)aniline 生成 N-phenyl-leucine nitrile
  参考文献：
  名称：

  v.Miller; Ploechl; Eibner, Chemische Berichte, 1892, vol. 25, p. 2043

  摘要：

  DOI：

文献信息

• One-pot three-component synthesis of α-amino nitriles catalyzed by nano powder TiO2 P 25
  作者：Seyed Meysam Baghbanian、Maryam Farhang、Robabeh Baharfar

  DOI：10.1016/j.cclet.2010.12.003

  日期：2011.5

  A simple and efficient method has been developed for the synthesis of α-amino nitriles from aldehydes, amines and trimethylsilyl cyanide (Me3SiCN) in the presence of a catalytic amount of cyanuric acid at room temperature.

  已开发出一种简单有效的方法，在室温下在催化量的氰尿酸存在下，由醛，胺和三甲基甲硅烷基氰化物（Me3SiCN）合成α-氨基腈。
• Fe(Cp)2PF6 catalyzed efficient Strecker reactions of ketones and aldehydes under solvent-free conditions
  作者：Noor-ul H. Khan、Santosh Agrawal、Rukhsana I. Kureshy、Sayed H.R. Abdi、Surendra Singh、Eringathodi Suresh、Raksh V. Jasra

  DOI：10.1016/j.tetlet.2007.11.136

  日期：2008.1

  The synthesis of alpha-aminonitriles of ketones and aldehydes was performed in very short reaction times (20 min) with excellent yields in the presence of 5 mol % of Fe(Cp)(2)PF6 under solvent-free conditions. (c) 2007 Published by Elsevier Ltd.
• Tin exchanged zeolite as catalyst for direct synthesis of α-amino nitriles under solvent-free conditions
  作者：Arpan K. Shah、Noor-ul H. Khan、Govind Sethia、S. Saravanan、Rukhsana I. Kureshy、Sayed H.R. Abdi、Hari C. Bajaj

  DOI：10.1016/j.apcata.2012.01.001

  日期：2012.3

  Sn exchanged HBeta zeolite was prepared and characterized by PXRD, surface area, TPD and TEM analysis. The Sn exchanged zeolite was found to be highly efficient catalyst for the direct synthesis of alpha-amino nitrite from various ketones and aldehydes with amine and trimethyl silylcyanide (TMSCN) under solvent-free condition. Excellent yield of alpha-amino nitrile (up to 96%) was achieved within 10-120 min at room temperature. The Sn exchanged HBeta zeolite was recovered and reused several times without the loss of its catalytic performance. (C) 2012 Elsevier B.V. All rights reserved.
• α-Aminoalkanesulfonic Acids^1,2
  作者：L. NEELAKANTAN、WALTER H. HARTUNG

  DOI：10.1021/jo01094a029

  日期：1959.12
• v. Miller; Ploechl; Eibner, Chemische Berichte, 1892, vol. 25, p. 2041
  作者：v. Miller、Ploechl、Eibner

  DOI：——

  日期：——