2-Ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)chromen-4-one | 314745-55-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 2-Ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)chromen-4-one
• CAS: 314745-55-6
• 化学式: C₁₉H₁₆N₂O₃
• mdl: MFCD01848029
• 分子量: 320.348
• InChiKey: YHYDMJJKEPQMTC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  64.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  丙酸酐 、 2-(2,4-dihydroxyphenacyl)-1-methylbenzimidazole 在 吡啶 、 盐酸 作用下， 以 乙醇 为溶剂， 反应 72.0h， 以65%的产率得到2-Ethyl-7-hydroxy-3-(1-methylbenzimidazol-2-yl)chromen-4-one
  参考文献：
  名称：

  Chemistry of hetero analogs of isoflavones 25. Synthesis of 2-alkyl-3-(2-benzimidazolyl)-chromones

  摘要：

  2-Alkyl-3-(1-methyl-2-benzimidazolyl)-7-acyloxychromones were synthesized by the reaction of substituted or unsubstituted 2-(2,4-dihydroxyphenacyl)-1-methylbenzimidazoles with the acid chlorides and anhydrides of carboxylic acids. The products were converted into 2-alkyl-7-hydroxychromones as a result of acid hydrolysis.

  DOI：

  10.1007/s10593-008-0015-7

文献信息

• Chemistry of hetero analogs of isoflavones 25. Synthesis of 2-alkyl-3-(2-benzimidazolyl)-chromones
  作者：M. S. Frasinyuk、V. P. Khilya

  DOI：10.1007/s10593-008-0015-7

  日期：2008.1

  2-Alkyl-3-(1-methyl-2-benzimidazolyl)-7-acyloxychromones were synthesized by the reaction of substituted or unsubstituted 2-(2,4-dihydroxyphenacyl)-1-methylbenzimidazoles with the acid chlorides and anhydrides of carboxylic acids. The products were converted into 2-alkyl-7-hydroxychromones as a result of acid hydrolysis.