N-(4-甲氧基苯基)-N,2-二甲基苯胺 | 82463-33-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(4-甲氧基苯基)-N,2-二甲基苯胺
• 英文名称: (4-methoxy-phenyl)-methyl-o-tolyl-amine
• 英文别名: Methyl-o-tolyl-p-anisidin；4-(Methyl-o-toluidino)-phenol-methylaether；4'-Methoxy-N.2-dimethyl-diphenylamin；N-(4-Methoxyphenyl)-N,2-dimethylaniline
• CAS: 82463-33-0
• 化学式: C₁₅H₁₇NO
• 分子量: 227.306
• InChiKey: LWICWEUOXXFFOR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  4-氯苯甲醚 、 N-甲基-邻甲基苯胺 在 SK-CC₀₂-A sodium t-butanolate 作用下， 以 1,4-二氧六环 为溶剂， 反应 2.0h， 以94%的产率得到N-(4-甲氧基苯基)-N,2-二甲基苯胺
  参考文献：
  名称：

  一种用于芳基氯化物胺化的新型高效钯催化剂

  摘要：

  已开发出一种用于 Buchwald-Hartwig 胺化的高活性催化剂。这种新催化剂是二甲基氨基甲基二茂铁钯环和双（2-降冰片基）膦的组合，在非或失活的芳基氯化物与伯胺和仲胺以及（受阻）苯胺的偶联方面表现出高活性和广泛的范围。

  DOI：

  10.1055/s-2004-835632

文献信息

• A New Efficient Palladium Catalyst for the Amination of Aryl Chlorides
  作者：Ulrike Nettekoven、Frédéric Naud、Anita Schnyder、Hans-Ulrich Blaser

  DOI：10.1055/s-2004-835632

  日期：——

  A highly active catalyst for the Buchwald-Hartwig amination has been developed. The new catalyst, a combination of a dimethylaminomethyl ferrocene palladacycle and bis(2-norbornyl)phosphine shows high activity and broad scope for the coupling of non- or deactivated aryl chlorides with primary and secondary amines as well as (hindered) anilines.

  已开发出一种用于 Buchwald-Hartwig 胺化的高活性催化剂。这种新催化剂是二甲基氨基甲基二茂铁钯环和双（2-降冰片基）膦的组合，在非或失活的芳基氯化物与伯胺和仲胺以及（受阻）苯胺的偶联方面表现出高活性和广泛的范围。
• Philip, Journal fur praktische Chemie (Leipzig 1954), 1886, vol. <2>34, p. 65
  作者：Philip

  DOI：——

  日期：——
• Novel organic electroluminescent compounds and organic electroluminescent device using the same
  申请人：Kim Young Gil

  公开号：US20100108997A1

  公开（公告）日：2010-05-06

  Provided are novel organic electroluminescent compounds, and organic electroluminescent devices comprising the same as electroluminescent material. Specifically, the organic electroluminescent compounds according to the present invention are represented by Chemical Formula (1): wherein, at least one substituent(s) among Ar 1 , Ar 2 , R 6 , R 7 , R 8 , R 9 , R 10 , R 11 , R 12 , R 13 , R 14 and R 15 represent(s) The organic electroluminescent compounds according to the present invention exhibit high luminous efficiency and excellent life property of material, so that an OLED having very good operation life can be manufactured therefrom. Further, the organic electroluminescent compound according to the present invention, when it is contained in an electroluminescent layer or a hole transport layer, lowers the operation voltage to result in noticeable decrease in power consumption, with exhibiting at least comparable luminous efficiency as compared to conventional OLED's.
• US4330473A
  申请人：——

  公开号：US4330473A

  公开（公告）日：1982-05-18
• NIXANTPHOS: a highly active ligand for palladium catalyzed Buchwald–Hartwig amination of unactivated aryl chlorides
  作者：Jianyou Mao、Jiadi Zhang、Shuguang Zhang、Patrick J. Walsh

  DOI：10.1039/c8dt01852a

  日期：——

  catalyzed Buchwald–Hartwig amination reactions, because of its broad scope and high probability of success. It does not, however, work well with unactivated aryl chlorides. Herein NIXANTPHOS is compared to Xantphos and an array of mono- and bidentate phosphines. NIXANTPHOS outperforms Xantphos and all other bidentate ligands examined. Under the optimal reaction conditions, unactivated aryl chlorides afford

  Xantphos是钯催化的Buchwald-Hartwig胺化反应中最常用的两种配体之一，因为它的作用范围广且成功的可能性很高。但是，它不适用于未活化的芳基氯化物。本文将NIXANTPHOS与Xantphos以及一系列单和双齿膦进行了比较。NIXANTPHOS优于Xantphos和所有其他双齿配体。在最佳反应条件下，未活化的芳基氯化物以低至0.05 mol％（500 ppm）的钯负载量提供了良好至优异收率的预期产物。