N-(5-溴-1,3-噻唑-2-基)-2,2-二甲基丙酰胺 | 840493-84-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(5-溴-1,3-噻唑-2-基)-2,2-二甲基丙酰胺
• 英文名称: N-(5-bromothiazol-2-yl)-2,2-dimethylpropanamide
• 英文别名: N-(5-Bromo-1,3-thiazol-2-YL)-2,2-dimethylpropanamide
• CAS: 840493-84-7
• 化学式: C₈H₁₁BrN₂OS
• mdl: MFCD12148406
• 分子量: 263.158
• InChiKey: YXGIOMZEOSAJJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  70.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-(5-溴-1,3-噻唑-2-基)-2,2-二甲基丙酰胺 在 水 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 为溶剂， 以99%的产率得到N-(4-bromothiazol-2-yl)-2,2-dimethylpropanamide
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326
• 作为产物：
  描述：

  2,2-dimethyl-N-thiazol-2-ylpropionamide 在 溴 、 三乙胺 作用下， 以 氯仿 为溶剂， 反应 3.0h， 以84%的产率得到N-(5-溴-1,3-噻唑-2-基)-2,2-二甲基丙酰胺
  参考文献：
  名称：

  Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines

  摘要：

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.

  DOI：

  10.1021/jo0484326

文献信息

• [EN] FUSED DIHYDROPYRANS AS GPR119 MODULATORS FOR THE TREATMENT OF DIABETES, OBESITY AND RELATED DISEASES<br/>[FR] DIHYDROPYRANNES FONDUS UTILISÉS COMME MODULATEURS DE GPR119 POUR TRAITER LE DIABÈTE, L'OBÉSITÉ ET LES MALADIES ASSOCIÉES
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2012080476A1

  公开（公告）日：2012-06-21

  The present invention relates to compounds of general formula (I), wherein the groups R1, LP, LQ, X1, X2, X3, Ar and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及一般式（I）的化合物，其中基团R1、LP、LQ、X1、X2、X3、Ar和n如申请中所定义，具有有价值的药理特性，特别是结合到GPR119受体并调节其活性。
• Compounds, pharmaceutical compositions and uses thereof
  申请人：HIMMELSBACH Frank

  公开号：US20120322784A1

  公开（公告）日：2012-12-20

  The present invention relates to compounds of formula I, wherein the groups R 1 , L P , L Q , X 1 , X 2 , X 3 , Ar and n are as defined in the application, which have valuable pharmacological properties, and in particular bind to the GPR119 receptor and modulate its activity.

  本发明涉及公式I的化合物， 其中R 1 ，LP，LQ，X 1 ，X 2 ，X 3 ，Ar和n的定义如申请中所述，具有有价值的药理特性，特别是结合GPR119受体并调节其活性。
• US8669271B2
  申请人：——

  公开号：US8669271B2

  公开（公告）日：2014-03-11
• Investigations of the Halogen Dance Reaction on N-Substituted 2-Thiazolamines
  作者：Peter Stanetty、Michael Schnürch、Kurt Mereiter、Marko D. Mihovilovic

  DOI：10.1021/jo0484326

  日期：2005.1.1

  DIAGRAMThe halogen dance (HD) reaction on various 2-thiazolamine systems was investigated providing an easy access to a series of 5-substituted 4-bromo-2-thiazolamine derivatives. We could Show that HD is a very favored process for the investigated systems and that prevention of HD is only possible when optimized reaction conditions and selected electrophiles are applied.