tert-butyl 1-[(4-bromophenyl)methyl]-6,8-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate | 1228098-87-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: tert-butyl 1-[(4-bromophenyl)methyl]-6,8-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
• CAS: 1228098-87-0
• 化学式: C₂₃H₂₈BrNO₄
• 分子量: 462.384
• InChiKey: IOHAWVBVPBLSDS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  29
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  48
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  tert-butyl 1-[(4-bromophenyl)methyl]-6,8-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate 在 盐酸 、 水 、 palladium diacetate 、 三苯基膦 作用下， 以 乙醚 、 异丙醇 为溶剂， 反应 16.5h， 生成 1-[[4-(2-Methoxyphenyl)phenyl]methyl]-1,2,3,4-tetrahydroisoquinoline-6,8-diol;hydrochloride
  参考文献：
  名称：

  Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents

  摘要：

  Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2'-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (25) demonstrated improved potency, and selectivity on C6 rat glioma vs cultured rat astrocytes (EC50 0.63 mu M vs. 10.85 mu M) compared to our recent lead molecule EDL-155 (EC50 1.5 mu M vs. 27.4 mu M). The isomers of 25 were isolated using a semi-preparative high-performance liquid chromatography (HPLC) method, and their in vitro biological evaluation revealed that (+) 25 was the most active, and it was nearly 21 fold more potent than (-) 25, suggesting the antiglioma profile is influenced by stereochemical factors.

  DOI：

  10.1007/s00044-010-9356-8
• 作为产物：
  描述：

  1-(4-bromobenzyl)-6,8-dimethoxy-3,4-dihydroisoquinoline 在 sodium tetrahydroborate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， 生成 tert-butyl 1-[(4-bromophenyl)methyl]-6,8-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate
  参考文献：
  名称：

  Synthesis and evaluation of new 1,2,3,4-tetrahydroisoquinoline analogs as antiglioma agents

  摘要：

  Novel tetrahydroisoquinoline (THI) analogs were designed, synthesized, and their antiglioma activity was evaluated. The results showed that 6,8-dimethoxy-1-(2'-methoxybiphenyl-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride (25) demonstrated improved potency, and selectivity on C6 rat glioma vs cultured rat astrocytes (EC50 0.63 mu M vs. 10.85 mu M) compared to our recent lead molecule EDL-155 (EC50 1.5 mu M vs. 27.4 mu M). The isomers of 25 were isolated using a semi-preparative high-performance liquid chromatography (HPLC) method, and their in vitro biological evaluation revealed that (+) 25 was the most active, and it was nearly 21 fold more potent than (-) 25, suggesting the antiglioma profile is influenced by stereochemical factors.

  DOI：

  10.1007/s00044-010-9356-8

文献信息

• 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES EFFECTIVE AS ANTIGLIOMA AGENTS, METHODS OF MAKING, AND THEIR USE
  申请人：Patil Renukadevi

  公开号：US20120059032A1

  公开（公告）日：2012-03-08

  Disclosed are tetrahydroisoquinoline-derivative compounds effective for killing cancer cells, shrinking tumor size, and treating cancer.

  公开了四氢异喹啉衍生物化合物，其对杀死癌细胞、缩小肿瘤大小和治疗癌症具有有效性。
• [EN] 1,2,3,4-TETRAHYDROISOQUINOLINE DERIVATIVES EFFECTIVE AS ANTIGLIOMA AGENTS, METHODS OF MAKING, AND THEIR USE<br/>[FR] DÉRIVÉS DE LA 1,2,3,4-TÉTRAHYDROISOQUINOLINE EFFICACES EN TANT QU'AGENTS ANTI-GLIOMES, PROCÉDÉS DE FABRICATION, ET LEUR UTILISATION
  申请人：UNIV TENNESSEE RES FOUNDATION

  公开号：WO2011022518A1

  公开（公告）日：2011-02-24

  Disclosed are tetrahydroisoquinoline-derivative compounds effective for killing cancer cells, shrinking tumor size, and treating cancer.