N-(6-氧代-3,7-二氢嘌呤-2-基)-2-苯氧基-乙酰胺 | 144782-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 中文名称: N-(6-氧代-3,7-二氢嘌呤-2-基)-2-苯氧基-乙酰胺
• 英文名称: N²-Phenoxyacetylguanine
• 英文别名: N2-Phenoxyacetyl Guanine；N-(6-oxo-1,7-dihydropurin-2-yl)-2-phenoxyacetamide
• CAS: 144782-23-0
• 化学式: C₁₃H₁₁N₅O₃
• 分子量: 285.262
• InChiKey: VXZMETBWWUIXNK-UHFFFAOYSA-N

物化性质

• 熔点：
  >280°C (dec.)
• 密度：
  1.57±0.1 g/cm3(Predicted)
• 溶解度：
  二甲基亚砜（微溶）

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  109
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(6-氧代-3,7-二氢嘌呤-2-基)-2-苯氧基-乙酰胺 、 Phenylsulfenyl <1-(13)C>-2,3,5-tri-O-benzoyl-β-D-ribofuranoside 在 三氟甲磺酸三甲基硅酯 作用下， 生成 、
  参考文献：
  名称：

  PhenylsulfenylD-ribofuranosides as efficient ribosyl donors: Application to the synthesis of [1′,-13C]-(deoxy)nucleosides

  摘要：

  Readily available phenylsulfenyl 2,3,5-tri-O-benzoyl-beta-D-ribofuranoside glycosylates silylated nucleobases in a fast, high-yielding and stereoselective reaction promoted by trimethylsilyl trifluoromethanesulfonate. The method has been applied to the synthesis of [1'-C-13] labelled nucleosides further transformed to building blocks ready for oligodeoxynucleotide construction.

  DOI：

  10.1016/s0040-4039(00)79089-7

文献信息

• METHOD OF SYNTHESIZING CYCLIC BISDINUCLEOSIDE
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1645561A1

  公开（公告）日：2006-04-12

  A compound represented by Formula [2]: wherein R2 and R3 each independently represent a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group or a hydroxyl group; and B2 and B3 each independently represent a nucleic acid base, or a salt thereof can be synthesized from a compound represented by Formula [1]: wherein R1 represents a hydrogen atom, a halogen atom, a methoxy group, a 2-methoxyethoxy group, or a hydroxyl group substituted with a hydroxyl protecting group; and B1 represents a nucleic acid base which may be protected.

  由式 [2] 表示的化合物： 其中 R2 和 R3 各自独立地代表氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或羟基；以及 B2 和 B3 各自独立地代表核酸碱基、 或其盐可以由式 [1] 所代表的化合物合成： 其中 R1 代表氢原子、卤素原子、甲氧基、2-甲氧基乙氧基或被羟基保护基取代的羟基；B1 代表可被保护的核酸碱基。
• RNA monomers containing 0-acetal levulinyl ester groups and their use in RNA microarrays
  申请人：THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY

  公开号：US10287313B2

  公开（公告）日：2019-05-14

  The present invention is directed to RNA monomers comprising O-acetal levulinyl protecting groups at the 2′ and/or the 5′-hydroxy functionalities of the ribose moiety. Said monomers may be incorporated into oligoribonucleotides or RNA polynucleotides. Furthermore, the invention is directed to methods for the synthesis of said RNA monomers, oligoribonucleotides and RNA polynucleotides, as well as methods for their deprotection and methods for the use of said compounds and compositions comprising said compounds. In particular, such compounds and compositions comprising them are used in methods for light-directed synthesis of RNA microarrays.

  本发明涉及在核糖分子的 2′和/或 5′-羟基官能团上含有 O-乙缩醛乙酰基保护基团的 RNA 单体。所述单体可与寡核苷酸或 RNA 多核苷酸结合。此外，本发明还涉及合成所述 RNA 单体、寡核苷酸和 RNA 多核苷酸的方法，以及它们的脱保护方法和使用所述化合物和包含所述化合物的组合物的方法。特别是，这些化合物和包含它们的组合物可用于 RNA 微阵列的光导合成方法。
• High throughput cell-based screening for aptamers
  申请人：MeiraGTx UK II Limited

  公开号：US11371077B2

  公开（公告）日：2022-06-28

  The invention provides eukaryotic cell-based screening methods to identify an aptamer that specifically binds a ligand, or a ligand that specifically binds an aptamer, using a polynucleotide cassette for the regulation of the expression of a reporter gene where the polynucleotide cassette contains a riboswitch in the context of a 5′ intron-alternative exon-3′ intron. The riboswitch comprises an effector region and an aptamer such that when the aptamer binds a ligand, reporter gene expression occurs.

  本发明提供了基于真核细胞的筛选方法，利用多核苷酸盒鉴定特异性结合配体的适配体，或特异性结合适配体的配体，以调控报告基因的表达，其中多核苷酸盒在5′内含子-替代外显子-3′内含子的上下文中含有核糖开关。核糖开关包括效应区和适配体，当适配体与配体结合时，报告基因就会表达。
• INTERMEDIATE FOR PRODUCTION OF NUCLEOSIDE ANALOGUE, AND METHOD FOR PRODUCING SAME
  申请人：Daiichi Sankyo Company, Limited

  公开号：EP2862868B1

  公开（公告）日：2020-04-08
• RNA MONOMERS CONTAINING O-ACETAL LEVULINYL ESTER GROUPS AND THEIR USE IN RNA MICROARRAYS
  申请人：The Royal Institution for the Advancement of Learning / McGill University

  公开号：EP2334692A1

  公开（公告）日：2011-06-22