N-ethyl-N-phenylbiguanide | 100133-87-7

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-ethyl-N-phenylbiguanide
• 英文别名: 1-ethyl-1-phenyl-biguanide；1-Aethyl-1-phenyl-biguanid；N-ethyl-N-phenylimidodicarbonimidic diamide；3-(diaminomethylidene)-1-ethyl-1-phenylguanidine
• CAS: 100133-87-7
• 化学式: C₁₀H₁₅N₅
• mdl: MFCD03615415
• 分子量: 205.263
• InChiKey: KZZXOYFLVCIWCW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  91.5
• 氢给体数：
  3
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-ethyl-N-phenylbiguanide 、 6-chloro-7-methyl-3-methylthio-1,4,2-benzodithiazin 1,1-dioxide 以 甲苯 为溶剂， 以59%的产率得到N-[4-Amino-6-(ethyl-phenyl-amino)-[1,3,5]triazin-2-yl]-4-chloro-2-mercapto-5-methyl-benzenesulfonamide
  参考文献：
  名称：

  Brzozowski, Zdzislaw, Acta poloniae pharmaceutica, 1998, vol. 55, # 1, p. 49 - 56

  摘要：

  DOI：
• 作为产物：
  描述：

  N-乙基苯胺盐酸盐 、 二聚氰胺 在 吡啶 作用下， 生成 N-ethyl-N-phenylbiguanide
  参考文献：
  名称：

  Hypoglycemic Agents. II.^1—3 Arylbiguanides

  摘要：

  DOI：

  10.1021/ja01523a059

文献信息

• Compound having immune disease treatment effect and use thereof
  申请人：THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY—ACADEMIC COOPERATION FOUNDATION

  公开号：US10100006B2

  公开（公告）日：2018-10-16

  Provided is a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present subject matter has effects of inhibiting the production of inflammatory cytokines, increasing the activity of regulatory T cells having immunoregulatory functions, inhibiting the production of auto-antibodies to regulate excessive immune responses, and inhibiting the differentiation of osteoclasts, and thus can be used for treating immune diseases, such as autoimmune disease, inflammatory disease, and transplant rejection diseases, which are caused by abnormal regulation of various kinds of immune response.

  本发明提供了一种能够有效预防和治疗免疫疾病的新型化合物及其用途。本发明的新型化合物具有抑制炎症细胞因子的产生、提高具有免疫调节功能的调节性 T 细胞的活性、抑制自身抗体的产生以调节过度的免疫反应、抑制破骨细胞的分化等作用，因此可用于治疗因各种免疫反应调节异常而导致的自身免疫性疾病、炎症性疾病和移植排斥性疾病等免疫性疾病。
• NOVEL COMPOUND HAVING IMMUNE DISEASE TREATMENT EFFECT AND USE THEREOF
  申请人：THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

  公开号：US20170114008A1

  公开（公告）日：2017-04-27

  The present invention relates to a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present invention has effects of inhibiting the production of inflammatory cytokines, increasing the activity of regulatory T cells having immunoregulatory functions, inhibiting the production of auto-antibodies to regulate excessive immune responses, and inhibiting the differentiation of osteoclasts, and thus can be used for treating immune diseases, such as autoimmune disease, inflammatory disease, and transplant rejection diseases, which are caused by abnormal regulation of various kinds of immune response
• Hypoglycemic Agents. II.^1—3 Arylbiguanides
  作者：Seymour L. Shapiro、Vincent A. Parrino、Elaine Rogow、Louis Freedman

  DOI：10.1021/ja01523a059

  日期：1959.7
• Brzozowski, Zdzislaw, Acta poloniae pharmaceutica, 1998, vol. 55, # 1, p. 49 - 56
  作者：Brzozowski, Zdzislaw

  DOI：——

  日期：——