8-prop-2-enylsulfanyl-7H-purine | 6307-06-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 8-prop-2-enylsulfanyl-7H-purine
• CAS: 6307-06-8
• 化学式: C₈H₈N₄S
• 分子量: 192.24
• InChiKey: NGIMNFJZDBLEQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  79.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Method for labeling and fragmenting DNA
  申请人：BIO MERIEUX

  公开号：US20030143555A1

  公开（公告）日：2003-07-31

  The invention relates to a method for labeling and fragmenting a single- or double-stranded deoxyribonucleic acid (DNA) comprising the following steps: chemically fragmenting the DNA by creating at least one abasic site on said DNA, attaching a marker to at least one of the fragments by means of a labeling reagent, said reagent covalently and predominantly coupling to at least one phosphate of said fragment. The invention finds a preferred application in the field of diagnosis.

  该发明涉及一种用于标记和分解单链或双链脱氧核糖核酸（DNA）的方法，包括以下步骤：通过在DNA上创建至少一个缺碱位点来化学分解DNA，通过标记试剂将标记物附着到至少一个片段上，该试剂以共价键和主要地耦合到至少一个片段的磷酸基。该发明在诊断领域中找到了一个首选的应用。
• [EN] PURINE COMPOUNDS USED AS CB2 AGONISTS<br/>[FR] COMPOSÉS DE PURINE UTILISÉS COMME AGONISTES DE CB2
  申请人：LILLY CO ELI

  公开号：WO2011123482A1

  公开（公告）日：2011-10-06

  A compound of the formula (I) and pharmaceutical compositions for the treatment of pain.

  公式（I）的化合物及用于治疗疼痛的药物组成。
• Labeling reagents, methods for synthesizing such reagents and methods for detecting biological molecules
  申请人：BIO MERIEUX

  公开号：US20030186448A1

  公开（公告）日：2003-10-02

  The present invention relates to a temperature-stable labeling reagent of formula: 1 in which R 1 represents H or an alkyl, aryl or substituted aryl group, R 2 represents a detectable marker or at least two detectable markers linked together by at least one multimeric structure, L is a linking arm containing a linear succession of at least two covalent bonds and n an integer equal to 0 or 1, R 3 and R 4 represent independently of each other: H, NO 2 , Cl, Br, F, I, R 2 -(L) n -Y—X—, OR, SR, NR 2 , R, NHCOR, CONHR, COOR with R=alkyl or aryl, A is a linking arm containing at least one covalent double bond allowing conjugation of the diazo functional group with the aromatic ring and u is an integer between 0 and 2, preferably equal to 0 or 1, and —Y—X— represents —CONH—, —NHCO—, —CH 2 O—, —CH 2 S—. The present invention also describes a method for synthesizing said markers as well as applications for labeling biological molecules, in particular nucleic acids, with a labeling reagent carrying the diazomethyl functional group. The invention finds a preferred application in the field of diagnosis.

  本发明涉及一种公式为1的温度稳定标记试剂： 其中，R1表示H或烷基、芳基或取代芳基基团，R2表示可检测的标记或至少两个通过至少一个多聚物结构连接在一起的可检测标记，L是含有至少两个共价键的线性链连接臂，n是等于0或1的整数，R3和R4分别独立地表示：H、NO2、Cl、Br、F、I、R2-(L)n-Y-X-、OR、SR、NR2、R、NHCOR、CONHR、COOR，其中R=烷基或芳基，A是含有至少一个共价双键的连接臂，允许将重氮甲基官能团与芳香环共轭，u是介于0和2之间的整数，优选等于0或1，而-Y-X-表示-CONH-、-NHCO-、-CH2O-或-CH2S-。 本发明还描述了一种合成所述标记的方法，以及使用携带重氮甲基官能团的标记试剂标记生物分子，特别是核酸的应用。 本发明在诊断领域中找到了一种首选应用。
• PURINE COMPOUNDS USED AS CB2 AGONISTS
  申请人：Hollinshead Sean Patrick

  公开号：US20120329809A1

  公开（公告）日：2012-12-27

  A compound of the formula (I) and pharmaceutical compositions for the treatment of pain.

  公式（I）的化合物和用于治疗疼痛的药物组合物。
• ARYL-AND ARYLAMINO-SUBSTITUTED HETEROCYCLES AS CORTICOTROPIN RELEASING HORMONE ANTAGONISTS
  申请人：Du Pont Pharmaceuticals Company

  公开号：EP0994860A1

  公开（公告）日：2000-04-26