1,2-Xylylenediamine | 1314961-99-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,2-Xylylenediamine
• 英文别名: o-Diaminoxylene；1,2-dimethylcyclohexa-3,5-diene-1,2-diamine
• CAS: 1314961-99-3
• 化学式: C₈H₁₄N₂
• mdl: MFCD19215109
• 分子量: 138.213
• InChiKey: SNTIUURUNLOWSH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  52
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-吡啶甲酸 、 1,2-Xylylenediamine 在 1,2-二氯乙烷 作用下， 以 吡啶 为溶剂， 以0.22 g (84%)的产率得到N,N'-bis(picolinoyl)-1,2-xylylenediamine
  参考文献：
  名称：

  Hemoregulatory compounds

  摘要：

  这项发明涉及具有血液调节活性的新化合物，可用于刺激造血和治疗病毒、真菌和细菌感染性疾病。

  公开号：

  US06191146B1

文献信息

• Novel combi-molecules having EGFR and DNA targeting properties
  申请人：Jean-Claude Bertrand

  公开号：US20060003970A1

  公开（公告）日：2006-01-05

  A series of new chemical agents that demonstrate anti-tumor activity are described. The new chemical agents combine two major mechanisms of anti-tumor action. In an embodiment, the agents are capable of both inhibiting EGFR and damaging DNA while also, upon degradation, degrading to an inhibitor of EGFR and to an agent capable of damaging DNA. Moreover, a novel series of molecules capable of releasing two moles of EGFR inhibitor and a potent bi-functional alkylating agent are also described.

  描述了一系列展示抗肿瘤活性的新化学试剂。这些新化学试剂结合了两种主要的抗肿瘤作用机制。在一个实施例中，这些试剂既能够抑制EGFR又能够损伤DNA，同时，在降解时，会降解为EGFR抑制剂和能够损伤DNA的试剂。此外，还描述了一系列新颖的分子，能够释放两摩尔的EGFR抑制剂和一种强效的双功能烷基化剂。
• Assay for vitamin B12 absorption and method of making labeled vitamin B12
  申请人：Anderson J. Peter

  公开号：US20060110322A1

  公开（公告）日：2006-05-25

  The invention provides methods for labeling vitamin B12 with 14 C, 13 C, tritium, and deuterium. When radioisotopes are used, the invention provides for methods of labeling B12 with high specific activity. The invention also provides labeled vitamin B12 compositions made in accordance with the invention.

  这项发明提供了使用14C、13C、氚和氘标记维生素B12的方法。当使用放射性同位素时，该发明提供了用高比活度标记B12的方法。该发明还提供了根据该发明制备的标记维生素B12组合物。
• XYLYLENEDIISOCYANATE COMPOSITION, RESIN, AND POLYMERIZABLE COMPOSITION
  申请人：Mitsui Chemicals, Inc.

  公开号：EP3444236A1

  公开（公告）日：2019-02-20

  A xylylene diisocyanate composition contains a xylylene diisocyanate and a chloromethylbenzyl isocyanate. The content ratio of the chloromethylbenzyl isocyanate is 0.2 ppm or more and below 600 ppm.

  一种二异氰酸酯组合物含有二异氰酸酯和异氰酸氯苄酯。氯甲基苄基异氰酸酯的含量比为 0.2 ppm 或以上，低于 600 ppm。
• Coated proppants containing a cured resin and methods for making and using same
  申请人：Georgia-Pacific Chemicals LLC

  公开号：US10066154B2

  公开（公告）日：2018-09-04

  Coated proppants can include a plurality of particles and one or more cured resin at least partially encasing or coating each of the particles. The cured resin, prior to curing, can be or include one or more treated aldehyde-based resins that can include one or more aldehyde-based resins and one or more polyamines. The polyamine can be or include one or more aromatic polyamines, one or more poly(C2-C5 alkylene) polyamines, or a mixture thereof. The coated proppant can have a dry crush strength of about 0.1 wt % to about 3 wt % at a pressure of about 55.2 MPa, based on the Proppant Crush Resistance Test Procedure under ISO 13503-2:2011.

  涂层支撑剂可包括多个颗粒和一种或多种至少部分包裹或涂覆每个颗粒的固化树脂。固化前的固化树脂可以是或包括一种或多种经过处理的醛基树脂，其中可以包括一种或多种醛基树脂和一种或多种多胺。多胺可以是或包括一种或多种芳香族多胺、一种或多种聚（C2-C5 亚烷基）多胺或它们的混合物。根据 ISO 13503-2:2011《支撑剂抗压测试程序》，涂层支撑剂在约 55.2 兆帕压力下的干压强度约为 0.1 重量％至约 3 重量％。
• Treated aldehyde-based resins containing polyamines and methods for making and using same
  申请人：Georgia-Pacific Chemicals LLC

  公开号：US10118983B2

  公开（公告）日：2018-11-06

  Treated aldehyde-based resins containing one or more polyamines and methods for making and same. The treated aldehyde-based resin can be or include an aldehyde-based resin and a polyamine. The polyamine can be or include one or more aromatic polyamines, one or more poly(C2-C5 alkylene) polyamines, or a mixture thereof. The treated aldehyde-based resin can include about 0.05 wt % to about 10 wt % of the polyamine, based on a solids weight of the aldehyde-based resin.

  含有一种或多种多胺的经处理醛基树脂及其制造方法。经处理的醛基树脂可以是或包括醛基树脂和多胺。多胺可以是或包括一种或多种芳香族多胺、一种或多种聚（C2-C5 亚烷基）多胺或它们的混合物。根据醛基树脂的固体重量，经处理的醛基树脂可包括约 0.05 重量％至约 10 重量％的多胺。