N-(四氢-2H-吡喃-4-基)-3-吡啶甲胺 | 885277-42-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-(四氢-2H-吡喃-4-基)-3-吡啶甲胺
• 英文名称: Pyridin-3-ylmethyl-(tetrahydro-pyran-4-YL)-amine
• 英文别名: N-(pyridin-3-ylmethyl)oxan-4-amine
• CAS: 885277-42-9
• 化学式: C₁₁H₁₆N₂O
• mdl: MFCD08059325
• 分子量: 192.26
• InChiKey: ATJWTRSJMKQBAB-UHFFFAOYSA-N

物化性质

• 沸点：
  329.3±37.0 °C(Predicted)
• 密度：
  1.08

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.545
• 拓扑面积：
  34.2
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• [EN] ALPHA-7 NEURONAL NICOTINIC RECEPTOR LIGANDS: COMPOSITIONS AND METHODS OF USE<br/>[FR] LIGANDS DU RECEPTEUR NICOTINIQUE NEURONAL ALPHA-7 : COMPOSITIONS ET METHODES D'UTILISATION
  申请人：TARGACEPT INC

  公开号：WO2004108668A2

  公开（公告）日：2004-12-16

  Patients susceptible to or suffering from disorders, such as central nervous system disorders, which are characterized by an alteration in normal neurotransmitter release, such as dopamine release (e.g., Parkinsonism, Parkinson's Disease, Tourette's Syndrome, attention deficient disorder, or schizophrenia), are treated by administering a 1-aza-2-(3-pyridyl)bicyclo[2.2.1]heptane, a 1-aza-2-(3-pyridyl)bicyclo [2.2.2] octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.1]octane, a 1-aza-2-(3-pyridyl)bicyclo[3.2.2]nonane, a 1-aza-7-(3-pyridyl) bicyclo[2.2.1]heptane, a 1-aza-3-(3-pyridyl)bicyclo[3.2.2]nonane, or a 1-aza-7-(3-pyridyl)bicyclo[3.2.2]nonane. The compounds can exist as individual stereoisomers, racemic mixtures, diastereomers and the like.