2-acryloyloxyethyl phosphorylcholine | 150120-15-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2-acryloyloxyethyl phosphorylcholine
• 英文别名: 2-[acryloyloxyethyl-2'-(trimethylammonium)ethyl]phosphate；2-Prop-2-enoyloxyethyl 2-(trimethylazaniumyl)ethyl phosphate
• CAS: 150120-15-3
• 化学式: C₁₀H₂₀NO₆P
• 分子量: 281.246
• InChiKey: QJLHJLYDAZGLQR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  18
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  84.9
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  丙烯酸羟乙酯 在 三乙胺 作用下， 以 乙腈 为溶剂， 反应 0.5h， 生成 2-acryloyloxyethyl phosphorylcholine
  参考文献：
  名称：

  HIGH MOLECULAR WEIGHT ZWITTERION-CONTAINING POLYMERS

  摘要：

  本发明提供了含有亲水基团和一种或多种功能剂的多臂高分子量聚合物，以及制备这种聚合物的方法。

  公开号：

  US20140024776A1

文献信息

• Biomimetic Honeycomb-Structured Surfaces Formed from Block Copolymers Incorporating Acryloyl Phosphorylcholine
  作者：Martina H. Stenzel、Thomas P. Davis

  DOI：10.1071/ch03124

  日期：——

  casting block copolymers composed of polystyrene and poly(acryloyl phosphorylcholine), so that they mimicked a cell membrane. The size of the pores and regularity of the hexagonal array is strongly dependent on the block length. The block copolymers were prepared via RAFT (reversible addition fragmentation transfer) polymerization leading to well-defined products with a good control over block sizes

  我们报告了仿生蜂窝结构多孔薄膜的制备。这些规则阵列是通过铸造由聚苯乙烯和聚（丙烯酰磷酸胆碱）组成的嵌段共聚物获得的，因此它们模拟了细胞膜。六边形阵列的孔的大小和规则性很大程度上取决于块的长度。嵌段共聚物是通过 RAFT（可逆加成碎片转移）聚合制备的，可得到定义明确的产品，并能很好地控制嵌段尺寸。
• DENDRITIC MOLECULES
  申请人：Monteiro Michael John

  公开号：US20120059173A1

  公开（公告）日：2012-03-08

  The invention relates to novel dendritic molecules and methods of making them. The dendritic molecules comprise arms, each of which arms is a polymer. The dendritic molecules can be synthesised by way of a reasonably small number of versatile and reliable step-wise reactions, especially click chemistry reactions. Chemical and structural heterogeneity is possible in the dendritic molecule. The invention also provides for surface and interior functionalisation of the molecule.

  该发明涉及新型树状分子及其制备方法。这些树状分子包括臂，每个臂都是一种聚合物。这些树状分子可以通过相对少量的多功能和可靠的逐步反应合成，特别是点击化学反应。树状分子中可能存在化学和结构上的异质性。该发明还提供了对分子的表面和内部功能化。
• DIOL (METH) ACRYLATE COMPOUND HAVING URETHANE BOND, METHOD FOR PRODUCING THE SAME, AND POLYMER THEREOF
  申请人：Kang Eui-chul

  公开号：US20100081780A1

  公开（公告）日：2010-04-01

  The present invention provides compounds having in their molecule a structure contributing to high hydrophilicity, and having high photopolymerizability, as well as polymers of such compounds, and a method for producing the compound. The compounds are diol (meth)acrylate having a urethane bond represented by the formula (1), and cyclic ketal (meth)acrylate having a urethane bond represented by the formula (2): (R 1 : H, —CH 3 ; R 2 : —(CH 2 )n-; R 3 : —(CH 2 )m-; n: 1-4; m: 1-8; (AO): C2-C4 oxyalkylene group; x: 0-1000; R 4 , R 5 : H, —CH 3 , —C 2 H 5 ).

  本发明提供了分子中具有高亲水性结构并具有高光聚合性的化合物，以及这些化合物的聚合物和合成该化合物的方法。这些化合物是具有尿素键的二元醇（甲基）丙烯酸酯，其表示为公式（1），以及具有尿素键的环状酮（甲基）丙烯酸酯，其表示为公式（2）：（R1：H，—CH3；R2：—（CH2）n-；R3：—（CH2）m-；n：1-4；m：1-8；（AO）：C2-C4氧烷基；x：0-1000；R4，R5：H，—CH3，—C2H5）。
• Measuring method and measuring reagent of C-reactive protein
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP1130396A1

  公开（公告）日：2001-09-05

  An object of the present invention is to provide a method and a reagent for measuring the subject substances containing high concentration of C-reactive protein without dilution while avoiding prozone phenomenon. C-reactive protein is measured with a compound having a phosphrylcholine group and a cationic group shown by the general formula (I) [in the formula (I), where R1, R2 and R3 stand for a hydrogen atom, substituted or non-substituted alkyl, or substituted or non-substituted alkenyl, and X- stands for an inorganic anion or an organic anion] and an antibody to C-reactive protein. Or, C-reactive protein is measured with a surface active agent having a phosphorylcholine group, a surface active agent having a cationic group shown by the formura (II) [Y1 stands for a hydrophobic group, and R1, R2 and R3 stand for a hydrogen atom, substituted or non-substituted alkyl, or substituted or non-substituted alkenyl], and an antibody to C-reactive protein. As an antibody to C-reactive protein, an antibody carried by a water-insoluble carrier such as latex made from polystyrene is preferable.

  本发明的目的是提供一种方法和一种试剂，用于在不稀释的情况下测量含有高浓度 C 反应蛋白的受试物质，同时避免出现原区现象。 C 反应蛋白是用具有磷酰胆碱基团和阳离子基团的通式（I）所示化合物[式（I）中，R1、R2 和 R3 代表氢原子、取代或未取代的烷基或取代或未取代的烯基，X- 代表无机阴离子或有机阴离子]和 C 反应蛋白抗体来测量的。或者，用具有磷酸胆碱基团的表面活性剂、具有阳离子基团的表面活性剂（如式（II）所示）[Y1 代表疏水基团，R1、R2 和 R3 代表氢原子、取代或未取代的烷基或取代或未取代的烯基]和 C 反应蛋白抗体来测定 C 反应蛋白。作为 C 反应蛋白抗体，最好是由水不溶性载体（如聚苯乙烯制成的胶乳）携带的抗体。
• HIGHLY REPRODUCIBLE AGGLUTINATION IMMUNOASSAY METHOD AND REAGENTS
  申请人：KYOWA MEDEX CO., LTD.

  公开号：EP1314982A1

  公开（公告）日：2003-05-28

  The present invention provides an agglutination immunoassay, wherein the agglutination of insoluble carrier particles such as latex are stabilized and uniformized to give good reproducibility, and a reagent therefor. In the agglutination immunoassay which comprises allowing an antigenic substance in a sample to bind to insoluble carrier particles carrying substantially neither antigens nor antibodies thereon, and allowing an antibody or an antibody complex which reacts specifically to the antigenic substance to bind to the antigenic substance to give a selective agglutination of the insoluble carrier particles, a homopolymer prepared by polymerization of a monomer such as 2-methacryloyloxyethyl phosphorylcholine having a phosphorylcholine group and a vinyl group, or a copolymer prepared by polymerization of a monomer having a phosphorylcholine group and a vinyl group, with a monomer having a vinyl group such as n-butyl methacrylate is used.

  本发明提供了一种凝集免疫测定方法，其中不溶性载体颗粒（如胶乳）的凝集被稳定和均匀化，以获得良好的重现性，本发明还提供了一种相应的试剂。凝集免疫测定包括让样品中的抗原物质与不溶性载体微粒结合，载体微粒上基本上既不携带抗原也不携带抗体，让与抗原物质发生特异性反应的抗体或抗体复合物与抗原物质结合，使不溶性载体微粒发生选择性凝集、使用由具有磷酰胆碱基团和乙烯基团的单体（如 2-甲基丙烯酰氧乙基磷酰胆碱）聚合制备的均聚物，或由具有磷酰胆碱基团和乙烯基团的单体与具有乙烯基团的单体（如甲基丙烯酸正丁酯）聚合制备的共聚物。