2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid | 76575-35-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid
• 英文别名: 4,5-dimethyl-2-oxo-6-thia-1,8-diazatricyclo[7.4.0.03,7]trideca-3(7),4,8,10,12-pentaene-12-carboxylic acid
• CAS: 76575-35-4
• 化学式: C₁₃H₁₀N₂O₃S
• 分子量: 274.3
• InChiKey: PKGBWXCJGQPLRR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  98.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid 、 5-氨基四氮唑 在 N,N'-羰基二咪唑 作用下， 生成 2,3-Dimethyl-4-oxo-N-1H-tetrazol-5-yl-4H-pyrido[1,2-a]thieno[2,3-d]-pyrimidine-7-carboxamide
  参考文献：
  名称：

  Synthesis and antiallergy activity of 4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidines

  摘要：

  A series of 4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidines with substitutions in the 2, 3, and 7 positions was prepared. The compounds were evaluated in the rat passive cutaneous anaphylaxis test for antiallergy activity. Several compounds had potent oral activity and were found to be superior to disodium cromoglycate and doxantrazole. Structure-activity relationships are discussed.

  DOI：

  10.1021/jm00139a021
• 作为产物：
  描述：

  6-氯烟酸 、 2-氨基-4,5-二甲基噻吩-3-羧酸乙酯 以there is obtained 0.2 g of 2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid的产率得到2,3-dimethyl-4-oxo-4H-pyrido[1,2-a]thieno[2,3-d]pyrimidine-7-carboxylic acid
  参考文献：
  名称：

  Oxo-pyrido[1,2-a]thienopyrimidine compounds and methods for their

  摘要：

  本发明揭示了Oxo-pyrido[1,2-a]thienopyrimidine化合物及其盐，生产方法，生产中间体，含有该化合物的制药组合物以及使用该组合物治疗过敏的方法。

  公开号：

  US04230707A1

文献信息

• Dihydro-oxo-pyrido[1,2-a]thienopyrimidine compounds
  申请人：Warner-Lambert Company

  公开号：US04287340A1

  公开（公告）日：1981-09-01

  Oxo-pyrido[1,2-a]thienopyrimidine compounds, salts thereof, methods of production, intermediates in their production, pharmaceutical compositions containing said compounds and methods for treating allergies using said compositions are disclosed.

  本发明公开了Oxo-pyrido[1,2-a]thienopyrimidine化合物及其盐、制备方法、制备中间体、含有该化合物的制药组合物以及使用该组合物治疗过敏的方法。
• Oxo-pyrido(1,2-a)thienopyrimidine compounds, processes for their production, and pharmaceutical compositions containing said compounds
  申请人：WARNER-LAMBERT COMPANY

  公开号：EP0025643A1

  公开（公告）日：1981-03-25

  There are disclosed oxo-pyrido[1,2-a]thienopyrimidine compounds having the three following formula: and salts thereof, wherein each of R and R', which are the same or different, is hydrogen, lower alkyl, chloro, bromo, phenyl, or a substituted phenyl in which the substituent is a lower alkyl, chloro, fluoro, or lower alkoxy; and Z is -CN, with Y being -OH, -NH2, lower alkoxy Also disclosed are processes for their production, intermediates for use in their production, process for producing the intermediates, pharmaceutical compositions containing said compounds, and methods or treating allergies using said compounds or said compositions.

  公开了具有以下三个式子的氧代吡啶并[1,2-a]噻吩嘧啶化合物： 及其盐类，其中相同或不同的R和R'各自为氢、低级烷基、氯、溴、苯基或取代苯基，其中取代基为低级烷基、氯、氟或低级烷氧基；Z为-CN、 Y为-OH、-NH2、低级烷氧基 还公开了其生产工艺、用于生产的中间体、生产中间体的工艺、含有所述化合物的药物组合物，以及使用所述化合物或所述组合物治疗过敏的方法。
• TINNEY, F. J.;CETENKO, W. A.;KERBLESKI, J. J.;CONNOR, D. T.;SORENSON, R. +, J. MED. CHEM., 1981, 24, N 7, 878-882
  作者：TINNEY, F. J.、CETENKO, W. A.、KERBLESKI, J. J.、CONNOR, D. T.、SORENSON, R. +

  DOI：——

  日期：——
• US4230707A
  申请人：——

  公开号：US4230707A

  公开（公告）日：1980-10-28
• US4287340A
  申请人：——

  公开号：US4287340A

  公开（公告）日：1981-09-01