1,1-dimethoxy-N,N-dimethylpropan-2-amine | 1246225-38-6

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1,1-dimethoxy-N,N-dimethylpropan-2-amine
• 英文别名: N,N-dimethylacetamide dimethyl acetal；N,N-dimethylformamide dimethylacetal；(1,1-Dimethoxypropan-2-yl)dimethylamine
• CAS: 1246225-38-6
• 化学式: C₇H₁₇NO₂
• 分子量: 147.217
• InChiKey: KEVDCDWLWBPODP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1,1-dimethoxy-N,N-dimethylpropan-2-amine 、 3-(2-fluorophenyl)-1-phenyl-1Hpyrazol-5(4H)-one 以 四氢呋喃 为溶剂， 反应 0.5h， 生成 4-(1-(dimethylamino)ethylidene)-5-(2-fluorophenyl)-2-phenyl-2,4-dihydro-3H-pyrazol-3-one
  参考文献：
  名称：

  Preparation of 2,4,5-trisubstituted pyrazolo[4,3-c]quinolin-3-ones

  摘要：

  The preparation of pyrazolo[4,3-c]quinolinones is reported starting from 2-substituted-5-(2-fluorophenyl)-3-oxo-2,4-dihydro-3H-pyrazol-3-ones. A one-pot protocol was developed, in which condensation with an orthoamide, followed by substitution with a primary amine and subsequent S(N)Ar-cyclization, to provide rapid access to 4- and 5-substituted pyrazolo[4,3-c]quinolinones. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.12.054

文献信息

• [EN] [1,2,4]TRIAZOLO[1,5-A]PYRIDINYL SUBSTITUTED INDOLE COMPOUNDS<br/>[FR] COMPOSÉS D'INDOLE SUBSTITUÉS PAR [1,2,4] TRIAZOLO [1,5-A] PYRIDINYLE
  申请人：BRISTOL MYERS SQUIBB CO

  公开号：WO2018005586A1

  公开（公告）日：2018-01-04

  Disclosed are compounds of Formula (I) or a salt thereof, wherein R1, R2, R3, R4, R5, m, n, and p are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

  揭示了Formula (I)或其盐的化合物，其中R1、R2、R3、R4、R5、m、n和p在此处被定义。还揭示了使用这些化合物作为通过Toll样受体7、8或9信号传导的抑制剂的方法，以及包含这些化合物的药物组合物。这些化合物在治疗炎症性和自身免疫性疾病方面是有用的。
• ORTHO PYRROLIDINE, BENZYL-SUBSTITUTED HETEROCYCLE CCR1 ANTAGONISTS FOR AUTOIMMUNE DISEASES & INFLAMMATION
  申请人：Paradkar Vidyadhar M.

  公开号：US20090093472A1

  公开（公告）日：2009-04-09

  Compounds of the formula are disclosed. The compounds are CCR1 antagonists which are useful for the treatment and prevention of inflammatory and autoimmune diseases. Other embodiments are also disclosed.

  公式为的化合物已被披露。这些化合物是CCR1拮抗剂，可用于治疗和预防炎症性和自身免疫性疾病。其他实施例也已披露。
• Novel 2-Cyano-3(Halo)Alkoxy-Benzenesulfonamide Compounds for Combating Animal Pests
  申请人：von Deyn Wolfgang

  公开号：US20080063678A1

  公开（公告）日：2008-03-13

  The invention relates to 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds I where the variables Alk and R 1 to R 5 are as defined in claim 1, and/or to their agriculturally useful salts. Moreover, the present invention relates to the use of compounds I and/or their salts for combating animal pests; agricultural compositions comprising such an amount of at least one compound of the general formula I and/or at least one agriculturally useful salt of I and at least one inert liquid and/or solid agronomically acceptable carrier that it has a pesticidal action and, if desired, at least one surfactant; and a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the formula I and/or at least one agriculturally acceptable salt thereof. a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a 2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the general formula I

  本发明涉及2-氰基-3-(卤)烷氧基苯磺酰胺化合物I，其中变量Alk和R1至R5如权利要求1所定义，以及/或其在农业上有用的盐。此外，本发明还涉及使用化合物I和/或其盐来对抗动物害虫；包含至少一种通式I化合物和/或至少一种I的农业有用盐及至少一种惰性液体和/或固体农业上可接受的载体的农业组合物，其具有杀虫作用，如有需要，还包括至少一种表面活性剂；以及一种对抗动物害虫的方法，其中将至少一种2-氰基-3-(卤)烷氧基苯磺酰胺化合物I的杀虫有效量与动物害虫、它们的栖息地、繁殖地、食物供应、植物、种子、土壤、区域、材料或环境接触，或者接触需要保护免受动物攻击或侵害的材料、植物、种子、土壤、表面或空间。本发明还涉及一种保护种子免受土壤昆虫和由此产生的植物根和茎免受土壤和叶面昆虫的方法，其中在播种前和/或发芽前将种子与通式I的2-氰基-3-(卤)烷氧基苯磺酰胺化合物接触。
• NOVEL 2-CYANO-3(HALO)ALKOXY-BENZENESULFONAMIDE COMPOUNDS FOR COMBATING ANIMAL PESTS
  申请人：Deyn Wolfgang von

  公开号：US20080306297A1

  公开（公告）日：2008-12-11

  Novel 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds for combating animal pests The invention relates to 2-cyano-3-(halo)alkoxy-benzenesulfonamide compounds I where the variables Alk and R 1 to R 5 are as defined in claim 1 , and/or to their agriculturally useful salts. Moreover, the present invention relates to the use of compounds I and/or their salts for combating animal pests; agricultural compositions comprising such an amount of at least one compound of the general formula I and/or at least one agriculturally useful salt of I and at least one inert liquid and/or solid agronomically acceptable carrier that it has a pesticidal action and, if desired, at least one surfactant; and a method of combating animal pests which comprises contacting the animal pests, their habit, breeding ground, food supply, plant, seed, soil, area, material or environment in which the animal pests are growing or may grow, or the materials, plants, seeds, soils, surfaces or spaces to be protected from animal attack or infestation with a pesticidally effective amount of at least one 2-cyano-3-(halo)alkoxy-benzenesulfonamide compound of the formula I and/or at least one agriculturally acceptable salt thereof. a method for the for the protection of seeds from soil insects and of the resulting plant's roots and shoots from soil and foliar insects comprising contacting the seeds before sowing and/or after pregermination with a 2-cyano-3-(halo)alkoxybenzenesulfonamide compound of the general formula I

  本发明涉及2-氰基-3-(卤代)烷氧基苯磺酰胺化合物I，其中变量Alk和R1至R5如权利要求1所定义，和/或其在农业上有用的盐。此外，本发明还涉及使用化合物I和/或其盐来对抗动物害虫的方法；包括至少一种通式I化合物和/或至少一种I的农业上有用的盐以及至少一种惰性液体和/或固体农业上可接受的载体的农业组合物，以产生杀虫作用，如果需要，还包括至少一种表面活性剂；以及一种对抗动物害虫的方法，其中将至少一种2-氰基-3-(卤代)烷氧基苯磺酰胺化合物I或其农业上可接受的盐以杀虫有效量接触动物害虫、它们的栖息地、繁殖地、食物供应、植物、种子、土壤、区域、材料或动物害虫生长或可能生长的环境以及需要保护免受动物攻击或侵染的材料、植物、种子、土壤、表面或空间。还涉及一种使用2-氰基-3-(卤代)烷氧基苯磺酰胺通式I化合物的方法，用于保护种子免受土壤昆虫和由此产生的植物根和茎免受土壤和叶面昆虫的侵害，在播种前和/或发芽前将种子与通式I的2-氰基-3-(卤代)烷氧基苯磺酰胺化合物接触。
• Novel pyrrolidine heterocycles as CCR1 antagonists
  作者：J. Robert Merritt、Ray James、Vidyadhar M. Paradkar、Chongwu Zhang、Ruiyan Liu、Jinqi Liu、Biji Jacob、Camelia Chiriac、Michael J. Ohlmeyer、Elizabeth Quadros、Pamela Wines、Jennifer Postelnek、Catherine M. Hicks、Weiqing Chen、Earl F. Kimble、Linda O’Brien、Nicole White、Hema Desai、Kenneth C. Appell、Maria L. Webb

  DOI：10.1016/j.bmcl.2010.07.082

  日期：2010.9

  A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptable pharmacokinetics and microsomal stability in rat and is suitable for further optimization and development. (c) 2010 Elsevier Ltd. All rights reserved.