methyl (2Z,4E)-5-[8-[tert-butyl(dimethyl)silyl]oxy-1,2,3,4-tetrahydrodibenzofuran-4-yl]-2-methoxy-4-methylpenta-2,4-dienoate | 1246172-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并呋喃
• 英文名称: methyl (2Z,4E)-5-[8-[tert-butyl(dimethyl)silyl]oxy-1,2,3,4-tetrahydrodibenzofuran-4-yl]-2-methoxy-4-methylpenta-2,4-dienoate
• CAS: 1246172-22-4
• 化学式: C₂₆H₃₆O₅Si
• 分子量: 456.654
• InChiKey: WRNBVTONGDMKNC-JVEFOBOXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.89
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  57.9
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  methyl (2Z,4E)-5-[8-[tert-butyl(dimethyl)silyl]oxy-1,2,3,4-tetrahydrodibenzofuran-4-yl]-2-methoxy-4-methylpenta-2,4-dienoate 在 锂硼氢 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Total syntheses of the proposed structures of cuevaene A

  摘要：

  Two proposed structures of cuevaene A were synthesized and the NMR spectra of both structures are proved to be inconsistent with those of the natural product. The structure of cuevaene A is still unclear and needs to be revised. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.133
• 作为产物：
  描述：

  、 diisopropyl (1-methoxy-1-methoxycarbonylmethyl)phosphonate 在 正丁基锂 、 二异丙胺 作用下， 以 四氢呋喃 为溶剂， 反应 3.5h， 以66.5 mg的产率得到methyl (2Z,4E)-5-[8-[tert-butyl(dimethyl)silyl]oxy-1,2,3,4-tetrahydrodibenzofuran-4-yl]-2-methoxy-4-methylpenta-2,4-dienoate
  参考文献：
  名称：

  Total syntheses of the proposed structures of cuevaene A

  摘要：

  Two proposed structures of cuevaene A were synthesized and the NMR spectra of both structures are proved to be inconsistent with those of the natural product. The structure of cuevaene A is still unclear and needs to be revised. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.06.133

文献信息

• Total syntheses of the proposed structures of cuevaene A
  作者：Yunxiu Chen、Jianfeng Huang、Bo Liu

  DOI：10.1016/j.tetlet.2010.06.133

  日期：2010.9

  Two proposed structures of cuevaene A were synthesized and the NMR spectra of both structures are proved to be inconsistent with those of the natural product. The structure of cuevaene A is still unclear and needs to be revised. (C) 2010 Elsevier Ltd. All rights reserved.