2,5-di(N-t-butylaminomethyl)furan | 130539-82-1

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,5-di(N-t-butylaminomethyl)furan
• 英文别名: N-[[5-[(tert-butylamino)methyl]furan-2-yl]methyl]-2-methylpropan-2-amine
• CAS: 130539-82-1
• 化学式: C₁₄H₂₆N₂O
• 分子量: 238.373
• InChiKey: GHHFVVMASCKCHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  37.2
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  呋喃 、 N-methoxymethyl-N-t-butyl(methylene)iminium chloride 以 乙腈 为溶剂， 以21%的产率得到2,5-di(N-t-butylaminomethyl)furan
  参考文献：
  名称：

  衍生自脂肪族伯胺的双（氨基）醚在仲胺和叔胺合成中的应用

  摘要：

  由脂族伯胺和苄胺与甲醛，乙醇或甲醇一起制备了一系列双（氨基）醚。它们与亲电试剂反应，得到N-烷基-N-烷氧基甲基-亚甲基亚胺盐，在与富电子芳族化合物的反应中生成仲胺和叔胺的混合物：与两种不同亲核试剂的顺序反应得到了预期的叔胺。

  DOI：

  10.1016/0040-4020(96)00026-9

文献信息

• A new route to secondary amines from bis-(alkoxymethyl)-alkylamines - the activation of an aminomethyl group and protection of the product by the same functional group
  作者：Martyn J. Earle、Robin A. Fairhurst、Harry Heaney、George Papageorgiou、Robert F. Wilkins

  DOI：10.1016/s0040-4039(00)97589-0

  日期：1990.1

  variety of acidic reagents affords good yields of N-alkoxymethyl-N-alkylmethyleneiminium salts which react with trimethylsilyl enol ethers, and nucleophilic aromatic substrates to form protected secondary amines or tertiary amines by domino reactions; silyl ketene acetals afford tertiary amines only.

  的治疗N，N- -双用各种酸性试剂，得到良好的产率的（烷氧基）烷基胺Ñ -alkoxymethyl- Ñ -alkylmethyleneiminium盐，其与三甲基甲硅烷烯醇醚反应，亲核芳族底物，通过多米诺形式保护的仲胺或叔胺反应; 甲硅烷基乙烯酮缩醛仅提供叔胺。
• Radical cascade-enabled synthesis of precision polymers with complex main-chain structures
  申请人：Trustees of Boston College

  公开号：US11186678B2

  公开（公告）日：2021-11-30

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

  本研究提供了可实现序列控制的开环聚合和开环聚合的自由基级联反应，用于受控合成具有复杂主链结构的聚合物。此外，还提供了简便的合成方法，从而获得由开环触发器和扩展主链结构组成的低应变大环单体。本公开进一步提供了对聚合物分子量和分子量分布进行出色控制的方法，高链端保真度使得制备具有明确结构的聚合物体系成为可能。此外，还提供了聚合物化学中自由基级联触发转化的一般性质，及其在合成具有定制功能的各种主链结构基团的聚合物中的应用。本摘要旨在作为在特定技术领域进行搜索的扫描工具，并非对本公开内容的限制。
• RADICAL CASCADE-ENABLED SYNTHESIS OF PRECISION POLYMERS WITH COMPLEX MAIN-CHAIN STRUCTURES
  申请人：Trustees of Boston College

  公开号：US20200216610A1

  公开（公告）日：2020-07-09

  Radical cascade reactions enabling sequence-controlled ring-closing polymerization and ring-opening polymerization for the controlled synthesis of polymers with complex main-chain structures are provided. Facile syntheses leading to low-strain macrocyclic monomers consisting of the ring-opening triggers and extended main-chain structures are also provided. The present disclosure further provides methods for excellent control over polymer molecular weights and molecular weight distributions and high chain-end fidelity allows for the preparation of polymeric systems with well-defined architectures. Further provided are the general nature of the radical cascade-triggered transformations in polymer chemistry, and its application to the synthesis of polymers with diverse main-chain structural motifs with tailored functions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
• The use of bis(aminol) ethers derived from aliphatic primary amines in the synthesis of secondary and tertiary amines
  作者：Harry Heaney、George Papageorgiou

  DOI：10.1016/0040-4020(96)00026-9

  日期：1996.3

  prepared from primary aliphatic amines and benzylamine together with formaldehyde and either ethanol or methanol; they were reacted with electrophiles to give N-alkyl-N-alkoxymethyl-methyleneiminium salts which gave mixtures of secondary and tertiary amines in reactions with electron rich aromatic compounds: sequential reactions with two different nucleophiles gave the expected tertiary amines.

  由脂族伯胺和苄胺与甲醛，乙醇或甲醇一起制备了一系列双（氨基）醚。它们与亲电试剂反应，得到N-烷基-N-烷氧基甲基-亚甲基亚胺盐，在与富电子芳族化合物的反应中生成仲胺和叔胺的混合物：与两种不同亲核试剂的顺序反应得到了预期的叔胺。