1,3-dimethylindolizine | 1029272-75-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯并吡啶类
• 英文名称: 1,3-dimethylindolizine
• CAS: 1029272-75-0
• 化学式: C₁₀H₁₁N
• 分子量: 145.204
• InChiKey: LHKOJRQJKYWHSV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-乙基吡啶 在 indium(III) acetate 、 苯甲酸 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 正己烷 、 1,2-二氯乙烷 为溶剂， 反应 21.0h， 生成 1,3-dimethylindolizine
  参考文献：
  名称：

  铟（III）催化的氮杂-onia-烯反应合成吲哚嗪

  摘要：

  已经开发了一种新的铟（III）催化反应，用于合成一系列吲哚嗪骨架。这种方法是高效率的，使2摩尔％的低催化剂负载（降到0.5摩尔％），并通过5-渲染以高收率产品外切-挖氮杂Conia烯反应。此外，还证明了以单锅协同方式将亲电试剂掺入生成的吡咯烷酮环中的可能性。最后，基于实验观察，提出了一种机制建议。

  DOI：

  10.1002/chem.201701820

文献信息

• HETEROCYCLIC COMPOUNDS AND EXPANSION AGENTS FOR HEMATOPOIETIC STEM CELLS
  申请人：Nishino Taito

  公开号：US20120128640A1

  公开（公告）日：2012-05-24

  An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells useful for improvement in the efficiency of gene transfer into hematopoietic stem cells for gene therapy useful for treatment of various disorders is provided. An expansion agent for hematopoietic stem cells and/or hematopoietic progenitor cells containing a compound represented by the formula (I) (wherein X, Y, Z, Ar 1 , R 1 , R 2 , R 3 , R 4 , R 5 , R6 and R 7 are as defined in the description), a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof, which can expand hematopoietic stem cells and/or hematopoietic progenitor cells.

  提供一种用于改善基因治疗中将基因转移至造血干细胞以治疗各种疾病的血液干细胞和/或造血祖细胞扩张剂。该扩张剂包含由式(I)表示的化合物（其中X、Y、Z、Ar1、R1、R2、R3、R4、R5、R6和R7如描述中所定义）、该化合物的互变异构体、前药或药学上可接受的盐或其溶剂，能够扩张血液干细胞和/或造血祖细胞。
• (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF
  申请人：Iizuka Masato

  公开号：US20130217878A1

  公开（公告）日：2013-08-22

  (Aza)indolizine derivatives represented by Formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In Formula (I), 0 to 2 of X 1 , X 2 , X 3 and X 4 are a nitrogen atom and the others are CR 1 ; one of T 1 and T 2 represents cyano and the other represents a group represented by Formula (A), with the proviso that when T 1 is cyano, at least one of X 1 to X 4 is a nitrogen atom; R 1 independently represents a hydrogen atom, a halogen atom, a hydroxy group, C 1-6 alkyl, C 1-6 alkoxy or the like; ring U represents a benzene ring or the like; m represents integral number from 0 to 2; R 2 independently represents a fluorine atom, a hydroxy group or the like.

  公式（I）表示的Aza吲哚啉衍生物具有黄嘌呤氧化酶抑制活性，并可用作预防或治疗与血清尿酸水平异常相关的疾病的药物，其前药，盐或类似物。在公式（I）中，X1，X2，X3和X4中的0至2个是氮原子，其余为CR1；T1和T2中的一个表示氰基，另一个表示由公式（A）表示的基团，但是当T1是氰基时，X1至X4中至少有一个是氮原子；R1独立地表示氢原子，卤素原子，羟基，C1-6烷基，C1-6烷氧基或类似物；环U表示苯环或类似物；m表示从0到2的整数；R2独立地表示氟原子，羟基或类似物。
• METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2765187A1

  公开（公告）日：2014-08-13

  An agent for inducing production of megakaryocytes and/or platelets from pluripotent stem cells which is useful for treatment of disease accompanied by a decrease in platelets is provided. A method for producing megakaryocytes and/or platelets, comprising separating hematopoietic progenitor cells from the septal cells in sac-like structures produced by pluripotent stem cells, and culturing the hematopoietic progenitor cells ex vivo in the presence of a compound represented by the formula (I) (wherein R1 to R7, W, X, Y, Z, Ar1 and n are as defined in the description) to differentiate them into megakaryocytes and/or platelets.

  提供了一种诱导多能干细胞产生巨核细胞和/或血小板的制剂，该制剂可用于治疗伴随血小板减少的疾病。 一种生产巨核细胞和/或血小板的方法，包括在多能干细胞产生的囊状结构中将造血祖细胞从隔细胞中分离出来，并在由式（I）代表的化合物（其中R1至R7、W、X、Y、Z、Ar1和n如描述中所定义）存在下体内外培养造血祖细胞，使其分化成巨核细胞和/或血小板。
• HETEROCYCLIC COMPOUND AND HEMATOPOIETIC STEM CELL AMPLIFIER
  申请人：Nissan Chemical Industries, Ltd.

  公开号：EP2439204B1

  公开（公告）日：2017-01-04
• Low Temperature Organocopper-Mediated Two-Component Cross Coupling/Cycloisomerization Approach Toward N-Fused Heterocycles
  作者：Dmitri Chernyak、Surendra Babu Gadamsetty、Vladimir Gevorgyan

  DOI：10.1021/ol8008705

  日期：2008.6.5

  Organocopper reagents smoothly react with heterocyclic propargyl mesylates at low temperature to produce Mused heterocycles. The copper reagent plays a "double duty" in this novel cascade transformation, which proceeds via an S(N)2' substitution followed by a subsequent cycloisomerization step.