3-oxo-4H-1,4-benzothiazine-6-carboxamide

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 3-oxo-4H-1,4-benzothiazine-6-carboxamide
• 化学式: C₉H₈N₂O₂S
• mdl: MFCD00462441
• 分子量: 208.24
• InChiKey: CRYSLYNGIGFGPK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  14
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.111
• 拓扑面积：
  97.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• RECOMBINANT TRANSMEMBRANE DOMAIN-DEFICIENT STING AS BIOMIMETIC PROTEIN CARRIER FOR CGAMP ENHANCED CANCER IMMUNOTHERAPY
  申请人：Northeastern University

  公开号：US20210277077A1

  公开（公告）日：2021-09-09

  Disclosed are compositions comprising a fusion protein and a STING agonist, wherein the fusion protein comprises STINGΔTM protein fused to a cell-penetrating domain or a nanobody to deliver STING agonists. Also disclosed are methods of treating cancer, which is achieved by a administering said compositions.