N-[(2,5-dimethoxyphenyl)methyleneamino]-2-(1-naphthyloxy)acetamide | 351506-12-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N-[(2,5-dimethoxyphenyl)methyleneamino]-2-(1-naphthyloxy)acetamide
• 英文别名: N-[(2,5-dimethoxyphenyl)methylideneamino]-2-naphthalen-1-yloxyacetamide
• CAS: 351506-12-2
• 化学式: C₂₁H₂₀N₂O₄
• 分子量: 364.401
• InChiKey: SRUGDVPJOBWWQY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  69.2
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-(萘-1-基氧基)乙酸乙酯 在 一水合肼 作用下， 以 乙醇 为溶剂， 反应 8.0h， 生成 N-[(2,5-dimethoxyphenyl)methyleneamino]-2-(1-naphthyloxy)acetamide
  参考文献：
  名称：

  (Naphthalen-1-yloxy)-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazide derivatives: synthesis, antimicrobial evaluation, and QSAR studies

  摘要：

  A series of (naphthalen-1-yloxy)-acetic acid hydrazides (1-36) was synthesized and screened, in vitro, for antibacterial, antifungal, and antiviral activities. The results of antiviral activity showed that none of the tested compounds was active against viruses at subtoxic concentrations. Further, the antimicrobial screening results demonstrated that compounds having 3,4,5-trimethoxy benzaldehyde (18), o-Br, p-CN (31), and m-NO2 acetophenone (32) substituents were the most active ones against tested strains. QSAR investigations revealed that multi-target QSAR models were effective in describing the antimicrobial activity.

  DOI：

  10.1007/s00044-011-9776-0

文献信息

• (Naphthalen-1-yloxy)-acetic acid benzylidene/(1-phenyl-ethylidene)-hydrazide derivatives: synthesis, antimicrobial evaluation, and QSAR studies
  作者：Rakesh Narang、Balasubramanian Narasimhan、Sunil Sharma

  DOI：10.1007/s00044-011-9776-0

  日期：2012.9

  A series of (naphthalen-1-yloxy)-acetic acid hydrazides (1-36) was synthesized and screened, in vitro, for antibacterial, antifungal, and antiviral activities. The results of antiviral activity showed that none of the tested compounds was active against viruses at subtoxic concentrations. Further, the antimicrobial screening results demonstrated that compounds having 3,4,5-trimethoxy benzaldehyde (18), o-Br, p-CN (31), and m-NO2 acetophenone (32) substituents were the most active ones against tested strains. QSAR investigations revealed that multi-target QSAR models were effective in describing the antimicrobial activity.