苯胺,N,N-二甲基-4-[(1E)-2-(2-萘基)乙烯基]- | 190079-27-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 中文名称: 苯胺,N,N-二甲基-4-[(1E)-2-(2-萘基)乙烯基]-
• 英文名称: (E)-N,N-dimethyl-4-(2-(naphthalen-2-yl)vinyl)anilin
• 英文别名: N.N-dimethyl-4-[trans-2-(naphthyl-(2))-vinyl]-aniline；N.N-Dimethyl-4-[trans-2-(naphthyl-(2))-vinyl]-anilin；(E)-N,N-Dimethyl-4-(2-(naphthalen-2-yl)vinyl)aniline；N,N-dimethyl-4-[(E)-2-naphthalen-2-ylethenyl]aniline
• CAS: 190079-27-7
• 化学式: C₂₀H₁₉N
• 分子量: 273.378
• InChiKey: RRDADBSXDJUDCW-BQYQJAHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  21
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2-萘甲醇 在 正丁基锂 、 三溴化磷 作用下， 以 四氢呋喃 、 乙醚 、 正己烷 、 苯 为溶剂， 反应 0.5h， 生成 苯胺,N,N-二甲基-4-[(1E)-2-(2-萘基)乙烯基]-
  参考文献：
  名称：

  Further Naphthylcombretastatins. An Investigation on the Role of the Naphthalene Moiety

  摘要：

  By synthesis and biological studies of new naphthalene analogues of combretastatins, we have found that the naphthalene is a good surrogate for the isovanillin moiety (3-hydroxy-4methoxyphenyl) of combretastatin A-4, always generating highly cytotoxic analogues when combined with the 3,4,5-trimethoxyphenyl or related systems. On the other hand, when the naphthalene replaces the 3,4,5-trimethoxyphenyl moiety, the cytotoxic activity is largely decreased. The most cytotoxic naphthalene analogues of combretastatins, which also produce inhibition of tubulin polymerization, exerted their antimitotic effects through microtubule network disruption and subsequent G(2)/M arrest of the cell cycle in human cancer cells.

  DOI：

  10.1021/jm0310737

文献信息

• Stilbene Derivatives And Their Use For Binding And Imaging Amyloid Plaques
  申请人：Kung F. Hank

  公开号：US20080108840A1

  公开（公告）日：2008-05-08

  This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.

  本发明涉及成像淀粉样沉积物的方法、标记化合物以及制备标记化合物用于成像淀粉样沉积物的方法。本发明还涉及化合物及制备化合物以抑制淀粉样蛋白聚集形成淀粉样沉积物的方法，以及将治疗剂输送到淀粉样沉积物的方法。
• Propargyl-Allenyl Isomerizations and Electrocyclizations for the Functionalization of Phosphonium Salts: One-Pot Synthesis of Polysubstituted Vinylbenzenes and Naphthalenes
  作者：Guoqing Zhao、Qianyun Zhang、Hongwei Zhou

  DOI：10.1002/adsc.201300573

  日期：2013.11.25

  AbstractPhosphonium salts are widely used in organic synthesis as the precursor of Wittig reagents but highly functionalized phosphonium salts are not readily available. We have developed a sequence of propargyl–allenyl isomerizations and electrocyclizations for the functionalization of phosphonium salts via simple starting materials, which may provide an efficient one‐pot synthesis of polysubstituted vinylbenzenes and naphthalenes.magnified image
• Haddow et al., Philosophical transactions of the Royal Society of London. Series A, Mathematical and physical sciences, 1948, vol. 241, p. 147,187
  作者：Haddow et al.

  DOI：——

  日期：——
• Excited-state proton transfer and excited-state de-hydrogen bonding of the push–pull styryl system
  作者：Shun-Li Wang、Guo-Yi Gao、Tong-Ing Ho、Li-Yu Yang

  DOI：10.1016/j.cplett.2005.08.146

  日期：2005.11

  The excited-state reaction of push-pull styryl system was studied in this work. In the excited state, compounds of 2-StP-NMe2, 2-StQ-NMe2, 4-StQ-NMe2 and 4-StP-NMe2 possess a sufficiently large acidity change for the proton transfer process to occur. For compounds 2-StT-NMe2 and 2-StN-NMe2 the acidity change is too small to induce the proton transfer process. A new type of excited-state de-hydrogen bond (ESDHB) process was observed in this study. It is possible to explore the polarity and HB effect of solvent simultaneously by using the ESDHB mechanism. (c) 2005 Elsevier B.V. All rights reserved.