1-methyl-2-(naphthalen-1-yl)indolizine | 380448-87-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1-methyl-2-(naphthalen-1-yl)indolizine
• 英文别名: 1-Methyl-2-naphthalen-1-ylindolizine
• CAS: 380448-87-3
• 化学式: C₁₉H₁₅N
• 分子量: 257.335
• InChiKey: YXXMCZRWQULFBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  4.4
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为产物：
  描述：

  2-乙基吡啶 、 3-(1-萘基)丙烯酸 在 1,10-菲罗啉 、 lithium acetate 、 copper diacetate 、 镍 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 36.0h， 以48%的产率得到1-methyl-2-(naphthalen-1-yl)indolizine
  参考文献：
  名称：

  Synthesis of Functionalized Indolizines via Copper-Catalyzed Annulation of 2-Alkylazaarenes with α,β-Unsaturated Carboxylic Acids

  摘要：

  A novel copper-catalyzed annulation of 2-alkylazaarenes with alpha,beta-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.

  DOI：

  10.1021/ol300067h

文献信息

• Synthesis of Functionalized Indolizines via Copper-Catalyzed Annulation of 2-Alkylazaarenes with α,β-Unsaturated Carboxylic Acids
  作者：Yuzhu Yang、Chunsong Xie、Yongju Xie、Yuhong Zhang

  DOI：10.1021/ol300067h

  日期：2012.2.17

  A novel copper-catalyzed annulation of 2-alkylazaarenes with alpha,beta-unsaturated carboxylic acids has been accomplished. This reaction featuring C-H olefination and decarboxylative amination processes provides a concise access to C-2 arylated indolizines from simple and readily available starting materials.