16,17α-epoxy-4-progesterone-3,20-dione

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 16,17α-epoxy-4-progesterone-3,20-dione
• 英文别名: wolfowitz oxide；16,17-Epoxyprogesterone；(1R,2S,6S,7S,10S,11R)-6-acetyl-7,11-dimethyl-5-oxapentacyclo[8.8.0.02,7.04,6.011,16]octadec-15-en-14-one
• 化学式: C₂₁H₂₈O₃
• 分子量: 328.452
• InChiKey: LHNVKVKZPHUYQO-CWNZLVRBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  24
• 可旋转键数：
  1
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.809
• 拓扑面积：
  46.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  16,17α-epoxypregnenolone 在 环己酮 、 aluminum isopropoxide 作用下， 以 甲苯 为溶剂， 反应 2.0h， 以85.6 g的产率得到16,17α-epoxy-4-progesterone-3,20-dione
  参考文献：
  名称：

  CN103113453

  摘要：

  公开号：

文献信息

• SKIN PERMEABLE PEPTIDE AND METHOD FOR USING SAME
  申请人：IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

  公开号：EP3336098A1

  公开（公告）日：2018-06-20

  The present disclosure is directed to providing a new skin-penetrating peptide, a fusion product with a biologically active substance bound using the same, a cosmetic composition containing the same and a pharmaceutical composition for external application to skin containing the same. The skin-penetrating peptide of the present disclosure is less likely to cause an immune response as compared to existing skin-penetrating peptides and exhibits remarkably improved skin permeability. Therefore, the biologically active substance can be effectively delivered through the skin, particularly through the stratum corneum.

  本公开旨在提供一种新的皮肤穿透肽、使用该肽与生物活性物质结合的融合产品、含有该肽的化妆品组合物以及含有该肽的用于皮肤外用的药物组合物。与现有的皮肤穿透肽相比，本公开的皮肤穿透肽引起免疫反应的可能性更小，而且皮肤渗透性显著提高。因此，生物活性物质可以有效地通过皮肤，特别是角质层输送。
• Skin-penetrating peptide and method for using same
  申请人：IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

  公开号：US10858395B2

  公开（公告）日：2020-12-08

  The present disclosure is directed to providing a new skin-penetrating peptide, a fusion product with a biologically active substance bound using the same, a cosmetic composition containing the same and a pharmaceutical composition for external application to skin containing the same. The skin-penetrating peptide of the present disclosure is less likely to cause an immune response as compared to existing skin-penetrating peptides and exhibits remarkably improved skin permeability. Therefore, the biologically active substance can be effectively delivered through the skin, particularly through the stratum corneum.

  本公开旨在提供一种新的皮肤穿透肽、使用该肽与生物活性物质结合的融合产品、含有该肽的化妆品组合物以及含有该肽的用于皮肤外用的药物组合物。与现有的皮肤穿透肽相比，本公开的皮肤穿透肽引起免疫反应的可能性更小，而且皮肤渗透性显著提高。因此，生物活性物质可以有效地通过皮肤，特别是角质层输送。
• SKIN PERMEATING AND CELL ENTERING (SPACE) PEPTIDES AND METHODS OF USE THEREOF
  申请人：The Regents of the University of California

  公开号：EP2638162A2

  公开（公告）日：2013-09-18
• Skin Permeating And Cell Entering (SPACE) Peptides and Methods of Use Thereof
  申请人：HSU Tracy

  公开号：US20120128756A1

  公开（公告）日：2012-05-24

  The present disclosure provides peptides and peptide compositions, which facilitate the delivery of an active agent or an active agent carrier wherein the compositions are capable of penetrating the stratum corneum (SC) and/or the cellular membranes of viable cells.
• Useful Pharmaceutical Salts of 7- [(3R, 4R) - 3 - Hydroxy -4 - Hydroxymethyl - Pyrrolidin -1- Ylmethyl] -3, 5-Dihydro-Pyrrolo [3, 2-D] Pyrimidin -4-One
  申请人：Bartley Gary

  公开号：US20120165526A1

  公开（公告）日：2012-06-28

  The present disclosure provides novel hemi- and mono-salts of 7-[(3R,4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3,5-dihydro-pyrrolo[3,2-d]pyrimidin-4-one (Compound 1) with various organic and inorganic acids. In one embodiment, the organic acid is a C4 organic diacids. The present disclosure further provides novel methods for preparing these salts. The novel monohydrates hemisalts of the C4 organic diacids are isostructural and can be prepared with different properties. Multiple acids can be used simultaneously and the proportion of acids can be varied offering the opportunity to select hemi-salts of compound 1 with desired properties.