N-[(1R)-2,3-dihydro-1H-inden-1-yl]-7H-purin-6-amine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N-[(1R)-2,3-dihydro-1H-inden-1-yl]-7H-purin-6-amine
• 化学式: C₁₄H₁₃N₅
• 分子量: 251.29
• InChiKey: YNJSUURWQOVWDV-LLVKDONJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  66.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE<br/>[FR] COMPOSITIONS ET LEURS MÉTHODE D'UTILISATION POUR LE TRAITEMENT D'UNE MALADIE NEURODEGENERATIVE ET MITOCHONDRIALE
  申请人：MITOKININ INC

  公开号：WO2020206363A1

  公开（公告）日：2020-10-08

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  本公开涉及含氮杂环类似物，制备含氮类似物的方法，以及使用这些类似物治疗与PINK1激酶活性相关的疾病的方法，包括但不限于神经退行性疾病、线粒体疾病、纤维化和/或心肌病。本摘要旨在作为在特定领域进行搜索的扫描工具，并不打算限制本发明。
• COMPOSITIONS AND METHODS OF USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE
  申请人：MITOKININ, INC.

  公开号：US20220162215A1

  公开（公告）日：2022-05-26

  The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.