4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-N-phenyl-butyramide | 885657-93-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-N-phenyl-butyramide
• 英文别名: 4-(2-methyl-4-oxoquinazolin-3-yl)-N-phenylbutanamide
• CAS: 885657-93-2
• 化学式: C₁₉H₁₉N₃O₂
• 分子量: 321.379
• InChiKey: AYSNZDMEOUYFSR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  61.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  邻乙酰胺苯甲酸內酯 以 乙醇 、 甲苯 为溶剂， 反应 3.0h， 生成 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-N-phenyl-butyramide
  参考文献：
  名称：

  Novel Approach for the Synthesis ofN-Substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides

  摘要：

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.

  DOI：

  10.1080/00397911.2010.497594

文献信息

• Novel Approach for the Synthesis of<i>N</i>-Substituted-4-(2-methyl-4-oxo-4<i>H</i>-quinazolin-3-yl)-butyramides
  作者：Mohammad Amir、Israr Ali

  DOI：10.1080/00397911.2010.497594

  日期：2011.7.15

  [image omitted] A simple and convenient method for the synthesis of N-substituted-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyramides has been reported. Several aromatic and aliphatic amide derivatives of 4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-butyric acid were prepared in 60-81% yields by refluxing it with different phosphazo compounds in toluene for approximately 1h.