6-Amino-9-(2-naphthalen-1-yloxyethyl)purine-8-sulfonic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-Amino-9-(2-naphthalen-1-yloxyethyl)purine-8-sulfonic acid
• 化学式: C₁₇H₁₅N₅O₄S
• 分子量: 385.4
• InChiKey: KEVSKMSNIZSQCU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  142
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• Small molecule inhibitors of RNA binding motif (RBM) proteins for the treatment of acute cellular injury
  申请人：University of Pittsburgh—Of the Commonwealth System of Higher Education

  公开号：US10857112B2

  公开（公告）日：2020-12-08

  A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula I: wherein at least one of R1-R8 is a sulfonic acid, a carboxylic acid, a phosphonic acid, a pharmaceutically acceptable salt of a sulfonic acid, a pharmaceutically acceptable salt of a carboxylic acid, a pharmaceutically acceptable salt of a phosphonic acid, a sulfonate ester, a carboxylate acid ester, or a phosphonate ester; and the remaining R1-R8 are each independently selected from hydrogen, halo, hydroxyl, nitro, nitroso, amino, substituted amino, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoy, alkenyloxy, substituted alkenyloxy, alkynyloxy, substituted alkynyloxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkynyl, substituted cycloalkynyl, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyl, substituted heterocyclyl, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylthio, substituted heterocyclylthio, cyano, acyl, acylamino, acyloxy, aminocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, cycloalkenylthio, substituted cycloalkenylthio, thiol, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylthio, substituted heteroarylthio, sulfonyl, or sulfonyloxy.

  一种治疗受试者细胞损伤的方法，包括向有需要的受试者施用治疗有效量的式 I 化合物： 其中至少一个 R1-R8 是磺酸、羧酸、膦酸、磺酸的药学上可接受的盐、羧酸的药学上可接 受的盐、膦酸的药学上可接受的盐、磺酸酯、羧酸酯或膦酸酯；以及 环烷基、取代的环烷基、环烯基、取代的环烯基、环炔基、环炔基、环烷氧基、取代的环 烷氧基、杂环基、取代的杂环基、杂环氧基、取代的杂环氧基杂环基硫基、取代的杂环基硫基、氰基、酰基、酰氨基、酰氧基、氨基羰基、氨基羰基氨基、氨基硫基、氨基磺酰基、磺酰氨基、芳基、取代的芳基、芳氧基、取代的芳氧基、芳硫基、取代的芳硫基、烷硫基、取代的烷硫基、环烷硫基、取代的环烷基硫基、环烯硫基、取代的环烯硫基、硫醇、杂芳基、取代的杂芳基、杂芳氧基、取代的杂芳氧基、杂芳硫基、取代的杂芳硫基、磺酰基或磺酰氧基。
• SMALL MOLECULE INHIBITORS OF RNA BINDING MOTIF (RBM) PROTEINS FOR THE TREATMENT OF ACUTE CELLULAR INJURY
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：US20150141488A1

  公开（公告）日：2015-05-21

  A method of treating a cellular injury in a subject comprising administering to a subject in need thereof, a therapeutically effective amount of a compound of formula I: wherein at least one of R 1 -R 8 is a sulfonic acid, a carboxylic acid, a phosphonic acid, a pharmaceutically acceptable salt of a sulfonic acid, a pharmaceutically acceptable salt of a carboxylic acid, a pharmaceutically acceptable salt of a phosphonic acid, a sulfonate ester, a carboxylate acid ester, or a phosphonate ester; and the remaining R 1 -R 8 are each independently selected from hydrogen, halo, hydroxyl, nitro, nitroso, amino, substituted amino, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoy, alkenyloxy, substituted alkenyloxy, alkynyloxy, substituted alkynyloxy, cycloalkyl, substituted cycloalkyl, cycloalkenyl, substituted cycloalkenyl, cycloalkynyl, substituted cycloalkynyl, cycloalkyloxy, substituted cycloalkyloxy, heterocyclyl, substituted heterocyclyl, heterocyclyloxy, substituted heterocyclyloxy, heterocyclylthio, substituted heterocyclylthio, cyano, acyl, acylamino, acyloxy, aminocarbonyl, aminocarbonylamino, aminothiocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, aryl, substituted aryl, aryloxy, substituted aryloxy, arylthio, substituted arylthio, alkylthio, substituted alkylthio, cycloalkylthio, substituted cycloalkylthio, cycloalkenylthio, substituted cycloalkenylthio, thiol, heteroaryl, substituted heteroaryl, heteroaryloxy, substituted heteroaryloxy, heteroarylthio, substituted heteroarylthio, sulfonyl, or sulfonyloxy.
• US9610266B2
  申请人：——

  公开号：US9610266B2

  公开（公告）日：2017-04-04