2-[1-(naphthalen-1-yl)-ethyl]-acrylic acid | 415974-10-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[1-(naphthalen-1-yl)-ethyl]-acrylic acid
• 英文别名: 2-Methylidene-3-naphthalen-1-ylbutanoic acid
• CAS: 415974-10-6
• 化学式: C₁₅H₁₄O₂
• 分子量: 226.275
• InChiKey: FBDUPLWFWXOHGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[1-(naphthalen-1-yl)-ethyl]-acrylic acid 在 sodium hydroxide 、 1-羟基苯并三唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 作用下， 以 甲醇 、 氯仿 为溶剂， 反应 18.0h， 生成 (S)-3-(1H-Indol-3-yl)-2-(2-mercaptomethyl-3-naphthalen-1-yl-butyrylamino)-propionic acid
  参考文献：
  名称：

  Toward an Optimal Joint Recognition of the S₁‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)

  摘要：

  The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three metallopeptidases-neutral endopeptidase (NEP, neprilysin), angiotensin-converting enzyme (ACE), and endothelin-converting enzyme (ECE-1)-we studied the common structural specificity of the S-1' subsites of these peptidases. Various mercaptoacyl amino acids of the general formula HS-CH2-CH(R-1')CO-Trp-OH, possessing more or less constrained R-1' side chains, were designed. The mercapto-acyl synthons contain one or two asymmetrical centers. The K-i values of the separated stereoisomers of the most efficient inhibitors were used to determine the stereochemical preference of each enzyme. A guideline for the joint inhibition of the three peptidases was obtained with the (2R,3R) isomer of compound 13b. Its K-i values on NEP, ACE, and ECE were 0.7, 43, and 26 nM, respectively.

  DOI：

  10.1021/jm0005454
• 作为产物：
  描述：

  2-Methylene-3-naphthalen-1-yl-butyric acid ethyl ester 在 sodium hydroxide 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以1.2 g的产率得到2-[1-(naphthalen-1-yl)-ethyl]-acrylic acid
  参考文献：
  名称：

  Toward an Optimal Joint Recognition of the S₁‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)

  摘要：

  The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three metallopeptidases-neutral endopeptidase (NEP, neprilysin), angiotensin-converting enzyme (ACE), and endothelin-converting enzyme (ECE-1)-we studied the common structural specificity of the S-1' subsites of these peptidases. Various mercaptoacyl amino acids of the general formula HS-CH2-CH(R-1')CO-Trp-OH, possessing more or less constrained R-1' side chains, were designed. The mercapto-acyl synthons contain one or two asymmetrical centers. The K-i values of the separated stereoisomers of the most efficient inhibitors were used to determine the stereochemical preference of each enzyme. A guideline for the joint inhibition of the three peptidases was obtained with the (2R,3R) isomer of compound 13b. Its K-i values on NEP, ACE, and ECE were 0.7, 43, and 26 nM, respectively.

  DOI：

  10.1021/jm0005454

文献信息

• CONDUCTIVE PASTE AND MIXTURE PASTE FOR LITHIUM ION BATTERY POSITIVE ELECTRODE
  申请人：KANSAI PAINT CO., LTD.

  公开号：EP3168904A1

  公开（公告）日：2017-05-17

  The present invention provides a conductive paste for positive electrodes of lithium-ion batteries and mixture paste for positive electrodes of lithium-ion batteries that have an easy-to-apply viscosity, even when a relatively small amount of a dispersant is incorporated. More specifically, the present invention provides a conductive paste for positive electrodes of lithium-ion batteries containing a dispersion resin (A), conductive carbon (B), and a solvent (C), the dispersion resin (A) being a copolymer of a monomer mixture comprising a polycyclic aromatic hydrocarbon-containing monomer (A-1) in an amount of 1 to 70 mass%, based on the total solids content.

  本发明提供了一种用于锂离子电池正极的导电浆料和用于锂离子电池正极的混合物浆料，即使加入相对少量的分散剂，也具有易于涂抹的粘度。更具体地说，本发明提供了一种用于锂离子电池正极的导电浆料，该浆料含有分散树脂（A）、导电碳（B）和溶剂（C），其中分散树脂（A）是一种单体混合物的共聚物，该单体混合物包括一种含多环芳烃的单体（A-1），根据总固体含量，其用量为 1 至 70 质量％。
• CONDUCTIVE PASTE FOR LITHIUM-ION BATTERY POSITIVE ELECTRODES AND MIXTURE PASTE FOR LITHIUM-ION BATTERY POSITIVE ELECTRODES
  申请人：KANSAI PAINT CO., LTD.

  公开号：EP3193398A1

  公开（公告）日：2017-07-19

  This invention relates to a conductive paste for lithium-ion battery positive electrodes and a mixture paste for a lithium ion battery positive electrode that have an easy-to-apply viscosity, even when a relatively small amount of a dispersion resin is incorporated. More specifically, the invention provides a conductive paste for lithium-ion battery positive electrodes, the conductive paste comprising a dispersion resin (A), conductive carbon (B), and a solvent (C), the dispersion resin (A) containing a resin (A1), the resin (A1) containing, as one constituent component, a polymerizable unsaturated group-containing monomer (A1-1) represented by a specific formula.

  本发明涉及一种用于锂离子电池正极的导电浆料和一种用于锂离子电池正极的混合浆料，即使加入相对少量的分散树脂，也具有易于涂抹的粘度。更具体地说，本发明提供了一种用于锂离子电池正极的导电浆料，该导电浆料由分散树脂（A）、导电碳（B）和溶剂（C）组成，分散树脂（A）中含有一种树脂（A1），该树脂（A1）作为一种组成成分，含有一种可聚合的含不饱和基团的单体（A1-1），该单体由特定的式子表示。
• Conductive paste and mixture paste for lithium ion battery positive electrode
  申请人：KANSAI PAINT CO., LTD.

  公开号：US10256472B2

  公开（公告）日：2019-04-09

  The present invention provides a conductive paste for positive electrodes of lithium-ion batteries and mixture paste for positive electrodes of lithium-ion batteries that have an easy-to-apply viscosity, even when a relatively small amount of a dispersant is incorporated. More specifically, the present invention provides a conductive paste for positive electrodes of lithium-ion batteries containing a dispersion resin (A), conductive carbon (B), and a solvent (C), the dispersion resin (A) being a copolymer of a monomer mixture comprising a polycyclic aromatic hydrocarbon-containing monomer (A-1) in an amount of 1 to 70 mass %, based on the total solids content.

  本发明提供了一种用于锂离子电池正极的导电浆料和用于锂离子电池正极的混合物浆料，即使加入相对少量的分散剂，也具有易于涂抹的粘度。更具体地说，本发明提供了一种用于锂离子电池正极的导电浆料，该浆料含有分散树脂（A）、导电碳（B）和溶剂（C），其中分散树脂（A）是一种单体混合物的共聚物，该单体混合物包括一种含多环芳烃的单体（A-1），根据总固体含量，其用量为 1 至 70 质量％。
• Conductive paste for lithium-ion battery positive electrodes and mixture paste for lithium-ion battery positive electrodes
  申请人：KANSAI PAINT CO., LTD.

  公开号：US10355281B2

  公开（公告）日：2019-07-16

  This invention relates to a conductive paste for lithium-ion battery positive electrodes and a mixture paste for a lithium ion battery positive electrode that have an easy-to-apply viscosity, even when a relatively small amount of a dispersion resin is incorporated. More specifically, the invention provides a conductive paste for lithium-ion battery positive electrodes, the conductive paste comprising a dispersion resin (A), conductive carbon (B), and a solvent (C), the dispersion resin (A) containing a resin (A1), the resin (A1) containing, as one constituent component, a polymerizable unsaturated group-containing monomer (A1-1) represented by a specific formula.

  本发明涉及一种用于锂离子电池正极的导电浆料和一种用于锂离子电池正极的混合浆料，即使加入相对少量的分散树脂，也具有易于涂抹的粘度。更具体地说，本发明提供了一种用于锂离子电池正极的导电浆料，该导电浆料由分散树脂（A）、导电碳（B）和溶剂（C）组成，分散树脂（A）中含有一种树脂（A1），该树脂（A1）作为一种组成成分，含有一种可聚合的含不饱和基团的单体（A1-1），该单体由特定的式子表示。
• Toward an Optimal Joint Recognition of the S₁‘ Subsites of Endothelin Converting Enzyme-1 (ECE-1), Angiotensin Converting Enzyme (ACE), and Neutral Endopeptidase (NEP)
  作者：Nicolas Inguimbert、Pascale Coric、Hervé Poras、Hervé Meudal、Franck Teffot、Marie-Claude Fournié-Zaluski、Bernard P. Roques

  DOI：10.1021/jm0005454

  日期：2002.3.1

  The formation of vasoconstrictors (e.g., angiotensin II and endothelin) and the inactivation of vasodilators (e.g., bradykinin and atrial natriuretic) by membrane-bound zinc metallopeptidases are key mechanisms in the control of blood pressure and fluid homeostasis. The way in which these peptides modulate physiological functions has been intensively studied. With the aim to develop compounds that can jointly block the three metallopeptidases-neutral endopeptidase (NEP, neprilysin), angiotensin-converting enzyme (ACE), and endothelin-converting enzyme (ECE-1)-we studied the common structural specificity of the S-1' subsites of these peptidases. Various mercaptoacyl amino acids of the general formula HS-CH2-CH(R-1')CO-Trp-OH, possessing more or less constrained R-1' side chains, were designed. The mercapto-acyl synthons contain one or two asymmetrical centers. The K-i values of the separated stereoisomers of the most efficient inhibitors were used to determine the stereochemical preference of each enzyme. A guideline for the joint inhibition of the three peptidases was obtained with the (2R,3R) isomer of compound 13b. Its K-i values on NEP, ACE, and ECE were 0.7, 43, and 26 nM, respectively.