N-[2-(乙氧基-甲基-膦基)氧乙基]-N-丙-2-基-丙-2-胺 | 57856-11-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: N-[2-(乙氧基-甲基-膦基)氧乙基]-N-丙-2-基-丙-2-胺
• 英文名称: O-ethyl O-2-(N,N-diisopropylamino)ethyl methylphosphonite
• 英文别名: Isopropyl aminoethylmethyl phosphonite；N-[2-[ethoxy(methyl)phosphanyl]oxyethyl]-N-propan-2-ylpropan-2-amine
• CAS: 57856-11-8
• 化学式: C₁₁H₂₆NO₂P
• 分子量: 235.307
• InChiKey: OIQVKKOBTVZIFE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  8
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  21.7
• 氢给体数：
  0
• 氢受体数：
  3

ADMET

毒理性

• 解毒与急救

/SRP:/ 立即急救：确保已经进行了充分的中和。如果患者停止呼吸，请开始人工呼吸，最好使用需求阀复苏器、球囊阀面罩设备或口袋面罩，按训练操作。如有必要，执行心肺复苏。立即用缓慢流动的水冲洗受污染的眼睛。不要催吐。如果患者呕吐，让患者向前倾或将其置于左侧（如果可能的话，头部向下）以保持呼吸道畅通，防止吸入。保持患者安静，维持正常体温。寻求医疗救助。 /毒物A和B/

/SRP:/ Immediate first aid: Ensure that adequate decontamination has been carried out. If patient is not breathing, start artificial respiration, preferably with a demand valve resuscitator, bag-valve-mask device, or pocket mask, as trained. Perform CPR if necessary. Immediately flush contaminated eyes with gently flowing water. Do not induce vomiting. If vomiting occurs, lean patient forward or place on the left side (head-down position, if possible) to maintain an open airway and prevent aspiration. Keep patient quiet and maintain normal body temperature. Obtain medical attention. /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 基本治疗：建立专利气道（如有需要，使用口咽或鼻咽气道）。如有必要，进行吸痰。观察呼吸不足的迹象，如有需要，辅助通气。通过非循环呼吸面罩以10至15升/分钟的速度给予氧气。监测肺水肿，如有必要，进行治疗……。监测休克，如有必要，进行治疗……。预防癫痫发作，如有必要，进行治疗……。对于眼睛污染，立即用水冲洗眼睛。在运输过程中，用0.9%的生理盐水（NS）持续冲洗每只眼睛……。不要使用催吐剂。对于摄入，如果患者能吞咽、有强烈的干呕反射且不流口水，则用温水冲洗口腔，并给予5毫升/千克，最多200毫升的水进行稀释……。在去污后，用干燥的无菌敷料覆盖皮肤烧伤……。/毒药A和B/

/SRP:/ Basic treatment: Establish a patent airway (oropharyngeal or nasopharyngeal airway, if needed). Suction if necessary. Watch for signs of respiratory insufficiency and assist ventilations if needed. Administer oxygen by nonrebreather mask at 10 to 15 L/min. Monitor for pulmonary edema and treat if necessary ... . Monitor for shock and treat if necessary ... . Anticipate seizures and treat if necessary ... . For eye contamination, flush eyes immediately with water. Irrigate each eye continuously with 0.9% saline (NS) during transport ... . Do not use emetics. For ingestion, rinse mouth and administer 5 mL/kg up to 200 mL of water for dilution if the patient can swallow, has a strong gag reflex, and does not drool ... . Cover skin burns with dry sterile dressings after decontamination ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 解毒与急救

/SRP:/ 高级治疗：对于昏迷、严重肺水肿或严重呼吸困难的病人，考虑进行口咽或鼻咽气管插管以控制气道。使用气囊面罩装置的正压通气技术可能有益。考虑使用药物治疗肺水肿……。对于严重的支气管痉挛，考虑给予β激动剂，如沙丁胺醇……。监测心率和必要时治疗心律失常……。开始静脉输注D5W /SRP: "保持开放"，最小流量/。如果出现低血容量的迹象，使用0.9%的生理盐水（NS）或乳酸林格氏液。对于伴有低血容量迹象的低血压，谨慎给予液体。注意液体过载的迹象……。使用地西泮或劳拉西泮治疗癫痫……。使用丙美卡因氢氯化物协助眼部冲洗……。 /Poisons A and B/

/SRP:/ Advanced treatment: Consider orotracheal or nasotracheal intubation for airway control in the patient who is unconscious, has severe pulmonary edema, or is in severe respiratory distress. Positive-pressure ventilation techniques with a bag valve mask device may be beneficial. Consider drug therapy for pulmonary edema ... . Consider administering a beta agonist such as albuterol for severe bronchospasm ... . Monitor cardiac rhythm and treat arrhythmias as necessary ... . Start IV administration of D5W /SRP: "To keep open", minimal flow rate/. Use 0.9% saline (NS) or lactated Ringer's if signs of hypovolemia are present. For hypotension with signs of hypovolemia, administer fluid cautiously. Watch for signs of fluid overload ... . Treat seizures with diazepam or lorazepam ... . Use proparacaine hydrochloride to assist eye irrigation ... . /Poisons A and B/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

实验室动物：神经毒性/ O-乙基-O'-(2-二异丙氨基乙基)甲磷酰亚胺(QL)，是形成乙基S-2-二异丙氨基乙基甲磷酰硫醇的中间体，在成年母鸡中评估其神经毒性。鸟类单次口服QL剂量范围为635至6080毫克/千克。QL处理的母鸡在给药后24小时内观察急性毒理学效应，并在给药后的24天内评估迟发性神经毒性。母鸡的口服LD50为1186毫克/千克。在QL处理后第6天及之后观察到神经功能障碍，表现为运动能力丧失。神经毒性酯酶(NTE)活性在暴露于化合物后24小时内未被抑制。在口服剂量大于或等于635 mg/kg的QL处理母鸡的外周神经系统中，观察到多灶性神经损伤。这些发现表明，QL暴露后存在神经损伤倾向。

/LABORATORY ANIMALS: Neurotoxicity/ O-ethyl-O'-(2-diisopropylaminoethyl) methylphosphonite (QL), an intermediate in the formation of ethyl S-2-diisopropylaminoethyl methylphosphonothiolate, was evaluated for neurotoxicity in the adult hen. Birds were given a single oral dose of QL ranging from 635 to 6080 mg/kg. The QL-treated hens were observed for up to 24 hr after dosing for acute toxicologic effects and over a 24 day post-dose period for evaluation of delayed neurotoxicity. The oral LD50 in hens is 1186 mg/kg. Neurologic dysfunction, as evidenced by motor incapacitation, was observed at 6 days and thereafter after treatment with QL. Neurotoxic esterase (NTE) activity was not inhibited at 24 hr after exposure to compound. Neural damage, multifocal in nature, was noted in the peripheral nervous system of QL-treated hens at dose levels greater than or equal to 635 mg/kg, oral dose. These findings indicate neural damage tendencies following QL exposure.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 非人类毒性摘录

遗传毒性...对于QL中性成分甲基膦酸（MP）和2-二异丙氨基乙醇（KB）... Ames试验对两者均为阴性。

/GENOTOXICITY/ ... For QL neutralent constituents methylphosphinic acid (MP) and 2-diisopropylaminoethanol (KB)... the Ames test was negative for both.

来源:Hazardous Substances Data Bank (HSDB)

反应信息

• 作为产物：
  描述：

  N,N-二异丙基乙醇胺 、 乙醇 、 甲基二氯膦 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 N-[2-(乙氧基-甲基-膦基)氧乙基]-N-丙-2-基-丙-2-胺
  参考文献：
  名称：

  用于化学武器公约核查的 O-烷基 O-2-(N,N-二烷基氨基)乙基烷基亚膦酸酯（膦酸酯）的气相色谱-质谱研究

  摘要：

  研究了一系列 O-烷基 O-2-(N,N-二烷基氨基) 乙基烷基亚膦酸酯 (膦酸酯) 的电子电离 (EI) 质谱，它们是神经毒剂的前体，用于化学武器公约 (CWC) 验证。构建并讨论了一般的 EI 碎裂途径。通过分析氘代类似物的碎片离子和密度泛函理论 (DFT) 计算，确认了建议的碎片结构。观察到的碎片离子是由于不同的碎裂途径，例如氢和 McLafferty+1 重排，烯烃、胺和烷氧基通过 α-或 β-裂解过程消除。碎片离子清楚地允许明确鉴定感兴趣的化合物，包括异构化合物的那些。

  DOI：

  10.1255/ejms.1234

文献信息

• Composite membrane and method for making the same
  申请人：——

  公开号：US20010050252A1

  公开（公告）日：2001-12-13

  A composite membrane and method for making the same, comprising a porous support and a polyamide surface. The subject membrane provides improved flux and/or rejection rates. The subject membrane is further capable of operating at lower operating pressures. The subject method includes reacting a polyfunctional amine with a polyfunctional acyl halide to form a polyamide. The method includes the step of contacting a complexing agent with the polyfunctional acyl halide prior substantial reaction between the polyfunctional acyl halide and a polyfunctional amine. The subject process is easily adapted to commercial scale manufacturing processes and is particularly suited for making nanofiltration and reverse osmosis composite membranes.

  一种复合膜及其制造方法，包括多孔支架和聚酰胺表面。该膜提高了通量和/或排斥率。该膜还能在较低的工作压力下工作。该方法包括将多官能团胺与多官能团酰基卤反应生成聚酰胺。该方法包括在多官能酰基卤与多官能胺发生实质性反应之前，将络合剂与多官能酰基卤接触。该主题工艺很容易适用于商业规模的制造工艺，尤其适用于制造纳滤和反渗透复合膜。
• COMPOSITE MEMBRANE AND METHOD FOR MAKING THE SAME
  申请人：DOW GLOBAL TECHNOLOGIES INC.

  公开号：EP1276551A2

  公开（公告）日：2003-01-22
• WATER COOLER TOWERS AND OTHER MAN-MADE AQUATIC SYSTEMS AS ENVIRONMENTAL COLLECTION SYSTEMS FOR AGENTS OF CONCERN
  申请人：BRIGMON ROBIN

  公开号：US20120137756A1

  公开（公告）日：2012-06-07

  An apparatus and process of using existing process water sources such as cooling towers, fountains, and waterfalls is provided in which the water sources are utilized as monitoring system for the detection of environmental agents which may be present in the environment. The process water is associated with structures and have an inherent filtering or absorbing capability available in the materials and therefore can be used as a rapid screening tool for quality and quantitative assessment of environmental agents.
• US5935862A
  申请人：——

  公开号：US5935862A

  公开（公告）日：1999-08-10
• US6337018B1
  申请人：——

  公开号：US6337018B1

  公开（公告）日：2002-01-08