N',N'''-dimethylethanediylidene-bis-thiophosphorohydrazidic acid tetra-O-propyl ester | 59895-89-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机硫代磷酸及其衍生物
• 英文名称: N',N'''-dimethylethanediylidene-bis-thiophosphorohydrazidic acid tetra-O-propyl ester
• 英文别名: 2,3-bis(dipropoxyphosphinothioylhydrazinylidene)butane
• CAS: 59895-89-5
• 化学式: C₁₆H₃₆N₄O₄P₂S₂
• 分子量: 474.566
• InChiKey: KTUUKHJFSPRMMW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.07
• 重原子数：
  28.0
• 可旋转键数：
  17.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  85.7
• 氢给体数：
  2.0
• 氢受体数：
  8.0

反应信息

• 作为产物：
  描述：

  O,O-二丙基硫代磷酰肼 、 2,3-丁二酮 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 生成 N',N'''-dimethylethanediylidene-bis-thiophosphorohydrazidic acid tetra-O-propyl ester
  参考文献：
  名称：

  Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones

  摘要：

  Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.

  DOI：

  10.1021/jm00231a010

文献信息

• Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones
  作者：L. A. Cates、Y. M. Cho、L. K. Smith、L. Williams、T. L. Lemke

  DOI：10.1021/jm00231a010

  日期：1976.9

  Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.