6-Azido-2-chlor-purin

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-Azido-2-chlor-purin
• 英文别名: 6-azido-2-chloro-7(9)H-purine；6-azido-2-chloro-7H-purine
• 化学式: C₅H₂ClN₇
• 分子量: 195.571
• InChiKey: XTXHDRNUGRFZQC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Method for synthesizing 2-chloro-9-(2-fluoro-beta-d-arabinofuranosyl)-9h-purin-6-amine
  申请人：——

  公开号：US20030023078A1

  公开（公告）日：2003-01-30

  2-Chloro-9-(2-deoxy-2-fluoro-&bgr;-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-&bgr;-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.

  2-氯-9-(2-脱氧-2-氟-&bgr;-D-阿拉伯糖呋喃核苷基)-9H-嘌呤-9-胺是通过将2-氯-6-取代嘌呤与受保护和活化的2-脱氧-2-氟-D-阿拉伯糖呋喃糖反应，并与氨等碱反应而合成的。当嘌呤反应物在6位取代卤素时，在与氨反应之前进行一步与碱金属醇反应的步骤。
• [EN] METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO- beta -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE<br/>[FR] PROCEDES DE SYNTHESE DE 2-CHLORO-9-(2-DEOXY-2-FLUORO- DOLLAR G(B)-D-ARABINOFURANOSYL)-9H-PURINE-6-AMINE
  申请人：SOUTHERN RES INST

  公开号：WO2001060383A1

  公开（公告）日：2001-08-23

  2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-9-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofuranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.

  2-氯-9-(2-去氧-2-氟-β-D-阿拉伯糖呋喃核苷基)-9H-嘌呤-9-胺是通过将2-氯-6-取代嘌呤与受保护和活化的2-去氧-2-氟-D-阿拉伯糖呋喃糖反应，并与氨等碱基反应而合成的。当嘌呤反应物在6位被卤素取代时，必须在与氨反应之前进行一步与碱金属醇反应的反应步骤。
• Methods for synthesizing 2-chloro-9-(2-deoxy-2-fluoro-B-D-arabinofuranosyl)-9H-purin-6-amine
  申请人：Montgomery A. John

  公开号：US20050288500A1

  公开（公告）日：2005-12-29

  2-Chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine is synthesized by reacting a 2-chloro-6-substituted purine with a protected and activated 2-deoxy-2-fluoro-D-arabinofiranose; and reacting with a base such as ammonia to provide 2-chloro-9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine. When the purine reactant is substituted in the 6 position with a halogen, a reaction step with an alkoxide is carried out prior to the reaction with ammonia.

  2-氯-9-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖基)-9H-嘌呤-6-胺的合成方法是：将 2-氯-6-取代的嘌呤与受保护和活化的 2-脱氧-2-氟-D-阿拉伯呋喃糖反应，然后与碱如氨反应，得到 2-氯-9-(2-脱氧-2-氟-β-D-阿拉伯呋喃糖基)-9H-嘌呤-6-胺。当嘌呤反应物的 6 位被卤素取代时，在与氨反应之前，先与烷氧基化合物进行反应。
• METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-BETA-D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE
  申请人：Southern Research Institute

  公开号：EP1261350B1

  公开（公告）日：2006-07-12
• METHODS FOR SYNTHESIZING 2-CHLORO-9-(2-DEOXY-2-FLUORO-$g(b)-D-ARABINOFURANOSYL)- i 9H /i -PURIN-6-AMINE
  申请人：Southern Research Institute

  公开号：EP1261350A1

  公开（公告）日：2002-12-04