7-bromo-1,2-dihydro-2,2-dimethylnaphthalen-1-one | 148925-38-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 7-bromo-1,2-dihydro-2,2-dimethylnaphthalen-1-one
• 英文别名: 7-bromo-2,2-dimethyl-1,2-dihydronaphthalen-1-one；7-Bromo-2,2-dimethylnaphthalen-1-one
• CAS: 148925-38-6
• 化学式: C₁₂H₁₁BrO
• 分子量: 251.123
• InChiKey: WFTNRCCNGWRULH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-bromo-1,2-dihydro-2,2-dimethylnaphthalen-1-one 在 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 以83%的产率得到7-bromo-2,2-dimethyl-3,4-epoxy-1,2,3,4-tetrahydronaphthalen-1-one
  参考文献：
  名称：

  2,2-Dialkylnaphthalen-1-ones as new potassium channel activators

  摘要：

  A new series of 2,2-dialkylnaphthalen-1-one potassium channel activators has been prepared, and their in vitro relaxant activities in isolated rat portal vein and guinea pig tracheal spirals as well as their oral antihypertensive effect in spontaneously hypertensive rats have been evaluated. The group of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethylnaphthalen-1-ones with an electron-withdrawing substituent at the 6-position contain the most active compounds and 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthalene-6-c arbonitrile, 17f (UR-8225), has been selected for further pharmacological development.

  DOI：

  10.1021/jm00067a011
• 作为产物：
  描述：

  7-bromo-2,2-dimethyl-3,4-dihydronaphthalen-1(2H)-one 在 氢氧化钾 、 N-溴代丁二酰亚胺(NBS) 、 过氧化氢苯甲酰 作用下， 生成 7-bromo-1,2-dihydro-2,2-dimethylnaphthalen-1-one
  参考文献：
  名称：

  2,2-Dialkylnaphthalen-1-ones as new potassium channel activators

  摘要：

  A new series of 2,2-dialkylnaphthalen-1-one potassium channel activators has been prepared, and their in vitro relaxant activities in isolated rat portal vein and guinea pig tracheal spirals as well as their oral antihypertensive effect in spontaneously hypertensive rats have been evaluated. The group of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethylnaphthalen-1-ones with an electron-withdrawing substituent at the 6-position contain the most active compounds and 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthalene-6-c arbonitrile, 17f (UR-8225), has been selected for further pharmacological development.

  DOI：

  10.1021/jm00067a011

文献信息

• Tetralones with pharmacological activity
  申请人：J. URIACH & CIA. S.A.

  公开号：EP0525768A1

  公开（公告）日：1993-02-03

  The present invention relates to new tetralones having the formula I: wherein R1-R7 and Z are as defined in Claim 1. The invention also relates to processes for their preparation and to pharmaceutical compositions containing them. These compounds are antihypertensive and bronchodilating agents.

  本发明涉及具有以下式I的新四酮： 其中R1-R7和Z如权利要求1所定义。本发明还涉及其制备过程以及含有它们的药物组合物。这些化合物是降压和支气管扩张剂。
• US5208246A
  申请人：——

  公开号：US5208246A

  公开（公告）日：1993-05-04
• US5272170A
  申请人：——

  公开号：US5272170A

  公开（公告）日：1993-12-21
• 2,2-Dialkylnaphthalen-1-ones as new potassium channel activators
  作者：Carmen Almansa、Luis A. Gomez、Fernando L. Cavalcanti、Ricardo Rodriguez、Elena Carceller、Javier Bartroli、Julian Garcia-Rafanell、Javier Forn

  DOI：10.1021/jm00067a011

  日期：1993.7

  A new series of 2,2-dialkylnaphthalen-1-one potassium channel activators has been prepared, and their in vitro relaxant activities in isolated rat portal vein and guinea pig tracheal spirals as well as their oral antihypertensive effect in spontaneously hypertensive rats have been evaluated. The group of 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethylnaphthalen-1-ones with an electron-withdrawing substituent at the 6-position contain the most active compounds and 1,2-dihydro-4-(1,2-dihydro-2-oxo-1-pyridyl)-2,2-dimethyl-1-oxonaphthalene-6-c arbonitrile, 17f (UR-8225), has been selected for further pharmacological development.