trans-3-Nitro-3'-methoxy-stilben | 14064-59-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二苯乙烯类
• 英文名称: trans-3-Nitro-3'-methoxy-stilben
• 英文别名: 1-[(E)-2-(3-methoxyphenyl)ethenyl]-3-nitrobenzene
• CAS: 14064-59-6
• 化学式: C₁₅H₁₃NO₃
• 分子量: 255.273
• InChiKey: RYWYACLLEYLWDB-CMDGGOBGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间硝基苯甲醛 、 (3-methoxybenzyl)triphenylphosphonium bromide 在 18-冠醚-6 、 potassium carbonate 作用下， 以 二氯甲烷 为溶剂， 反应 5.0h， 生成 (Z)-1-methoxy-3-[2-(3-nitrophenyl)ethenyl]benzene 、 trans-3-Nitro-3'-methoxy-stilben
  参考文献：
  名称：

  Separation of α-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRα-selective antagonists

  摘要：

  Liver X receptor (LXR) alpha/beta dual agonists are candidate medicaments for the treatment of metabolic syndrome, because their biological actions include increasing cholesterol efflux mediated by LXR beta. However, their clinical application is currently limited by their enhancing effect on triglyceride (TG) synthesis mediated by LXR alpha. Combination of an LXR alpha-selective antagonist with an LXR alpha/beta dual agonist may overcome this disadvantage. In the present work, structural development studies of phenethylphenyl phthalimide 9, which possesses LXR alpha/beta dual-antagonistic activity and alpha-glucosidase-inhibitory activity, led to the LXR alpha-selective antagonist 23f. Specific alpha-glucosidase inhibitors were also obtained. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2009.05.066

文献信息

• RADIATION CURABLE PHOTOCHROMIC INKS
  申请人：Iftime Gabriel

  公开号：US20070211110A1

  公开（公告）日：2007-09-13

  An ink that may be used in ink jet devices is a photochromic ink comprising an ink vehicle that includes at least one radiation curable component, at least one photochromic material and at least one photoinitiator. The ink is cured via exposure to radiation that cures the at least one radiation curable component of the ink. A radiation curable ink capable of exhibiting photochromatic color changes, which may be used to indicate a document's authenticity, is thus achieved.
• PHOTOCHROMIC SECURITY ENABLED INK FOR DIGITAL OFFSET PRINTING APPLICATIONS
  申请人：Iftime Gabriel

  公开号：US20130305947A1

  公开（公告）日：2013-11-21

  An ink composition useful for digital offset printing applications comprises a photochromic material and a plurality of curable compounds. The compounds have Hansen solubility parameters as described herein, and the resulting ink composition is both compatible with certain dampening fluids and has certain rheological properties, including a low viscosity. The photochromic ink compositions are useful for providing security information in certain printing applications.
• US5551973A
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  公开号：US5551973A

  公开（公告）日：1996-09-03
• US5593486A
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  公开号：US5593486A

  公开（公告）日：1997-01-14
• US5633109A
  申请人：——

  公开号：US5633109A

  公开（公告）日：1997-05-27