2-[2]naphthylamino-butyric acid | 100710-67-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 2-[2]naphthylamino-butyric acid
• 英文别名: α-(β-Naphthylamino)-buttersaeure；2-[2]Naphthylamino-buttersaeure；2-(Naphthalen-2-ylamino)butanoic acid
• CAS: 100710-67-6
• 化学式: C₁₄H₁₅NO₂
• 分子量: 229.279
• InChiKey: FFCFTZLYRSYEME-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-[2]naphthylamino-butyric acid 生成 N-丙基萘-2-胺
  参考文献：
  名称：

  Bischoff; Mintz, Chemische Berichte, 1892, vol. 25, p. 2324

  摘要：

  DOI：
• 作为产物：
  描述：

  2-溴丁酸 、 2-萘胺 在 水 作用下， 生成 2-[2]naphthylamino-butyric acid
  参考文献：
  名称：

  Bischoff; Mintz, Chemische Berichte, 1892, vol. 25, p. 2324

  摘要：

  DOI：

文献信息

• Receptor(SSTR4)-selective somatostatin analogs
  申请人：Rivier E. F. Jean

  公开号：US20050245438A1

  公开（公告）日：2005-11-03

  Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA 1,2,4,5,12,13 [Ala 7 ]-SRIF; des-AA 1,2,4,5,12,13 [Aph 7 ]-SRIF, des-AA 1,2,4,5,12,13 [Aph 7 ]Cbm-SRIF; des-AA 1,2,4,5,12,13 [Tyr 2 ,Ala 7 ]-Cbm-SRIF, and des-AA 1,2,4,5,12,13 [Tyr 7 ,C β Me-L-2Nal 8 ]-SRIF, and counterparts incorporating D-Cys 3 and/or D-Trp 8 and/or Ala 11 , bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.

  SRIF的类似物，其选择性针对SSTR4而不是其他克隆的SRIF受体，对于确定受体SSTR4在组织和细胞表达以及其在调节肿瘤生长中的生物学作用非常有用。SRIF类似物肽，例如des-AA1,2,4,5,12,13[Ala7]-SRIF；des-AA1,2,4,5,12,13[Aph7]-SRIF；des-AA1,2,4,5,12,13[Aph7]Cbm-SRIF；des-AA1,2,4,5,12,13[Tyr2,Ala7]-Cbm-SRIF和des-AA1,2,4,5,12,13[Tyr7,CβMe-L-2Nal8]-SRIF以及包含D-Cys3和/或D-Trp8和/或Ala11的对应物，与克隆的人类受体SSTR4具有高亲和力并激活受体，但它们不与人类SSTR1、SSTR2、SSTR3或SSTR5结合。通过在这些SSTR4选择性SRIF类似物中将碘化酪氨酸置于位置2，提供了一种在药物筛选方法中有用的标记化合物。或者，用于治疗的话，可以将细胞毒素或高放射性元素与其N-端耦合或配合。
• US7238775B2
  申请人：——

  公开号：US7238775B2

  公开（公告）日：2007-07-03
• [EN] RECEPTOR (SSTR4)- SELECTIVE SOMATOSTATIN ANALOGS<br/>[FR] ANALOGUES DE LA SOMASTATINE SELECTIFS DU RECEPTEUR (SSTR4)
  申请人：SALK INST FOR BIOLOGICAL STUDI

  公开号：WO2004009614A2

  公开（公告）日：2004-01-29

  Analogs of SRIF which are selective for SSTR4 in contrast to the other cloned SRIF receptors are useful in determining tissue and cellular expression of the receptor SSTR4 and its biological role in regulating tumor growth. SRIF analog peptides, such as des-AA1,2,4,5,12,13 [Ala7] -SRIF; des­-AA1,2,4,5,12,13 [Aph7] -SRIF, des-AA1'2,4,5,12,13 [Aph7] Cbm-SRIF; des­AA1,4,5,12,13 [Tyr2 Ala7] -Cbm-SRIF, and des-AA1'2,4,5,12,13 [Tyr7, CBMe-L­2Nal8]-SRIF, and counterparts incorporating D-Cys3 and/or D­Trp8 and/or Ala11, bind with high affinity to the cloned human receptor SSTR4 and activate the receptor, but they do not bind with significant affinity to human SSTR1, SSTR2, SSTR3 or SSTR5. By incorporating an iodinated tyrosine in position-2 in these SSTR4-selective SRIF analogs, a labeled compound useful in drug-screening methods is provided. Alternatively, for use in therapy, cytotoxins or highly radioactive elements can be N-terminally coupled or complexed thereto.
• Bischoff; Mintz, Chemische Berichte, 1892, vol. 25, p. 2324
  作者：Bischoff、Mintz

  DOI：——

  日期：——