N-(4-methoxyphenyl)-2-(piperazin-1-yl)-9H-purin-6-amine | 1236431-77-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: N-(4-methoxyphenyl)-2-(piperazin-1-yl)-9H-purin-6-amine
• 英文别名: N-(4-methoxyphenyl)-2-piperazin-1-yl-7H-purin-6-amine
• CAS: 1236431-77-8
• 化学式: C₁₆H₁₉N₇O
• 分子量: 325.373
• InChiKey: PCKCXNYUARJIGR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  91
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  哌嗪 、 2-chloro-6-(4-methoxyphenyl)amino-9H-purin 在 sodium tetrahydroborate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.08h， 生成 N-(4-methoxyphenyl)-2-(piperazin-1-yl)-9H-purin-6-amine
  参考文献：
  名称：

  Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase

  摘要：

  We report here the discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase by adopting a strategy integrating focused combinatorial library design, virtual screening, chemical synthesis, and bioassay. Thirty two compounds were selected and synthesized. All compounds showed potent inhibitory activity against c-Src kinase with IC50 values ranging from 3.14 mu M to 0.02 mu M. Compound 5i was identified as one of the most potent agent with an IC50 120 times lower than those of the hits. The high hit rate (100%) and the potency of the new Src kinase inhibitors demonstrated the efficiency of the strategy for the focused library design and virtual screening. The novel active chemical entities reported here should be good leads for further development of purine-based anticancer drugs targeting Src tyrosine kinase. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2010.05.032

文献信息

• Discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase
  作者：He Huang、Jingui Ma、Jianmei Shi、Linghua Meng、Hualiang Jiang、Jian Ding、Hong Liu

  DOI：10.1016/j.bmc.2010.05.032

  日期：2010.7

  We report here the discovery of novel purine derivatives with potent and selective inhibitory activity against c-Src tyrosine kinase by adopting a strategy integrating focused combinatorial library design, virtual screening, chemical synthesis, and bioassay. Thirty two compounds were selected and synthesized. All compounds showed potent inhibitory activity against c-Src kinase with IC50 values ranging from 3.14 mu M to 0.02 mu M. Compound 5i was identified as one of the most potent agent with an IC50 120 times lower than those of the hits. The high hit rate (100%) and the potency of the new Src kinase inhibitors demonstrated the efficiency of the strategy for the focused library design and virtual screening. The novel active chemical entities reported here should be good leads for further development of purine-based anticancer drugs targeting Src tyrosine kinase. (C) 2010 Elsevier Ltd. All rights reserved.