6-Hydroxy-8-(α-hydroxy-benzyl)-purin | 4244-54-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: 6-Hydroxy-8-(α-hydroxy-benzyl)-purin
• 英文别名: 8-(hydroxy-phenyl-methyl)-1,7(9)-dihydro-purin-6-one；8-[Hydroxy(phenyl)methyl]-1,7-dihydropurin-6-one；8-[hydroxy(phenyl)methyl]-1,7-dihydropurin-6-one
• CAS: 4244-54-6
• 化学式: C₁₂H₁₀N₄O₂
• 分子量: 242.237
• InChiKey: IEXFYTIDIVBVEO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  90.4
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME
  申请人：Michels Aaron

  公开号：US20150038480A1

  公开（公告）日：2015-02-05

  The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.
• US9629848B2
  申请人：——

  公开号：US9629848B2

  公开（公告）日：2017-04-25
• [EN] COMPOUNDS THAT MODULATE AUTOIMMUNITY AND METHODS OF USING THE SAME<br/>[FR] COMPOSÉS QUI MODULENT L'AUTO-IMMUNITÉ ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV COLORADO REGENTS

  公开号：WO2012162697A1

  公开（公告）日：2012-11-29

  The invention provides methods of preventing, treating or ameliorating autoimmune diseases, such as diabetes and celiac disease, by decreasing the binding of MHC class II molecules to antigenic peptides or fragments of antigenic peptides of the autoimmune disease by the administration of small organic compounds. The invention also provides pharmaceutical compositions comprising the therapeutically effective small organic compounds and methods of using the same.