2-(methylsulfonyl)oxirane | 1039122-77-4

• 分子结构分类: 有机化合物 - 有机硫化合物 - 磺酰类
• 英文名称: 2-(methylsulfonyl)oxirane
• 英文别名: 2-methylsulfonyloxirane
• CAS: 1039122-77-4
• 化学式: C₃H₆O₃S
• 分子量: 122.145
• InChiKey: CVYAOODREIIGDR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  7
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  甲基乙烯砜 在 叔丁基过氧化氢 、 正丁基锂 作用下， 以 四氢呋喃 、 癸烷 、 正己烷 为溶剂， 反应 2.5h， 以26%的产率得到2-(methylsulfonyl)oxirane
  参考文献：
  名称：

  Electrolyte for rechargeable lithium battery and rechargeable lithium battery

  摘要：

  一种用于可充电锂电池的电解质和包括该电解质的可充电锂电池，所述电解质包括非水有机溶剂；锂盐；和添加剂，其中所述添加剂包括化学式1所表示的化合物： 在化学式1中，R是取代或未取代的C1至C10烷基，取代或未取代的C1至C10烷氧基，取代或未取代的C2至C10烯基，取代或未取代的C2至C10炔基，取代或未取代的C3至C10环烷基，取代或未取代的C3至C10环烯基或取代或未取代的C6至C20芳基，n为1至3的整数。

  公开号：

  US10998580B2

文献信息

• 2-(甲基磺酰基)-环氧乙烷及其衍生物的制备方法
  申请人：石家庄圣泰化工有限公司

  公开号：CN113444059A

  公开（公告）日：2021-09-28

  2‑(甲基磺酰基)‑环氧乙烷及其衍生物的制备方法，属于环氧乙烷衍生物合成的技术领域，包括如下步骤：原料为乙烯基甲基砜或烯丙基甲基砜或甲基烯丙基磺酸酯，将有机溶剂溶解后的原料按质量比1:2:4分三份，分三次逐滴加入到间氯过氧苯甲酸中，加入时间分别为30min，25min，10min，升温回流15‑30h，冷却至室温过滤，得产物；原料为乙烯基甲基砜时，产物为2‑(甲基磺酰基)‑环氧乙烷；原料为烯丙基甲基砜时，产物为甲基‑2,3‑环氧丙烷磺酸酯；原料为甲基烯丙基磺酸酯时，产物为甲基‑2,3‑环氧丙烷磺酸酯；原料与间氯过氧苯甲酸的摩尔比为1:(1.8‑2.4)；本发明制备方法简单，收率高。
• Electrolyte for rechargeable lithium battery and rechargeable lithium battery
  申请人：SAMSUNG SDI CO., LTD.

  公开号：US10998580B2

  公开（公告）日：2021-05-04

  An electrolyte for a rechargeable lithium battery and a rechargeable lithium battery including the electrolyte, the electrolyte including a non-aqueous organic solvent; a lithium salt; and an additive, wherein the additive includes a compound represented by Chemical Formula 1: wherein, in Chemical Formula 1, R is a substituted or unsubstituted C1 to C10 alkyl group, a substituted or unsubstituted C1 to C10 alkoxy group, a substituted or unsubstituted C2 to C10 alkenyl group, a substituted or unsubstituted C2 to C10 alkynyl group, a substituted or unsubstituted C3 to C10 cycloalkyl group, a substituted or unsubstituted C3 to C10 cycloalkenyl group, or a substituted or unsubstituted C6 to C20 aryl group, and n is an integer of 1 to 3.

  一种用于可充电锂电池的电解质和包括该电解质的可充电锂电池，所述电解质包括非水有机溶剂；锂盐；和添加剂，其中所述添加剂包括化学式1所表示的化合物： 在化学式1中，R是取代或未取代的C1至C10烷基，取代或未取代的C1至C10烷氧基，取代或未取代的C2至C10烯基，取代或未取代的C2至C10炔基，取代或未取代的C3至C10环烷基，取代或未取代的C3至C10环烯基或取代或未取代的C6至C20芳基，n为1至3的整数。
• Design, Synthesis, and Evaluation of 2-(arylsulfonyl)oxiranes as Cell-permeable Covalent Inhibitors of Protein Tyrosine Phosphatases
  作者：Dibyendu Dana、Tirtha K. Das、Ish Kumar、Anibal R. Davalos、Kevin J. Mark、Daryl Ramai、Emmanuel J. Chang、Tanaji T. Talele、Sanjai Kumar

  DOI：10.1111/j.1747-0285.2012.01437.x

  日期：2012.10

  A structure‐based design approach has been applied to develop 2‐(arylsulfonyl)oxiranes as potential covalent inhibitors of protein tyrosine phosphatases. A detailed kinetic analysis of inactivation by these covalent inhibitors reveals that this class of compounds inhibits a panel of protein tyrosine phosphatases in a time‐ and dose‐dependent manner, consistent with the covalent modification of the enzyme active site. An inactivation experiment in the presence of sodium arsenate, a known competitive inhibitor of protein tyrosine phosphatase, indicated that these inhibitors were active site bound. This finding is consistent with the mass spectrometric analysis of the covalently modified protein tyrosine phosphatase enzyme. Additional experiments indicated that these compounds remained inert toward other classes of arylphosphate‐hydrolyzing enzymes, and alkaline and acid phosphatases. Cell‐based experiments with human A549 lung cancer cell lines indicated that 2‐(phenylsulfonyl)oxirane (1) caused an increase in intracellular pTyr levels in a dose‐dependent manner thereby suggesting its cell‐permeable nature. Taken together, the newly identified 2‐(arylsulfonyl)oxiranyl moiety could serve as a novel chemotype for the development of activity‐based probes and therapeutic agents against protein tyrosine phosphatase superfamily of enzymes.