1-(4-Benzylamino-piperidin-1-yl)-ethanone | 577778-36-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-(4-Benzylamino-piperidin-1-yl)-ethanone
• 英文别名: 1-(4-(Benzylamino)piperidin-1-yl)ethan-1-one；1-[4-(benzylamino)piperidin-1-yl]ethanone
• CAS: 577778-36-0
• 化学式: C₁₄H₂₀N₂O
• mdl: MFCD12494683
• 分子量: 232.326
• InChiKey: RMISNISLNWYSJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(4-Benzylamino-piperidin-1-yl)-ethanone 在 palladium on activated charcoal 、 甲酸铵 作用下， 以 甲醇 为溶剂， 以74%的产率得到1-乙酰基-4-氨基哌啶
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2
• 作为产物：
  描述：

  N-乙酰基-4-哌啶酮 、 苄胺 在 titanium(IV) isopropylate 、 sodium cyanoborohydride 作用下， 以 乙醇 为溶剂， 以85%的产率得到1-(4-Benzylamino-piperidin-1-yl)-ethanone
  参考文献：
  名称：

  4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs

  摘要：

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00437-2

文献信息

• 4-Aminopiperidine derivatives as a new class of potent cognition enhancing drugs
  作者：Dina Manetti、Elisabetta Martini、Carla Ghelardini、Silvia Dei、Nicoletta Galeotti、Luca Guandalini、Maria Novella Romanelli、Serena Scapecchi、Elisabetta Teodori、Alessandro Bartolini、Fulvio Gualtieri

  DOI：10.1016/s0960-894x(03)00437-2

  日期：2003.7

  Extrusion of one of the nitrogens of the piperazine ring of potent nootropic drugs previously described gave 4-amino-piperidine analogues that maintained high cognition enhancing activity in the mouse passive avoidance test. One of the new compounds (9. active at 0.01 mg/kg ip) may represent a new lead for the development of cognition enhancers useful to treat the cognitive deficit produced by neurodegenerative pathologies like Alzheimer's disease. (C) 2003 Elsevier Science Ltd. All rights reserved.