4-hydroxy-1-pentofuranosylpyrimidine-2(1H)-thione

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷
• 英文名称: 4-hydroxy-1-pentofuranosylpyrimidine-2(1H)-thione
• 英文别名: 1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-sulfanylidenepyrimidin-4-one
• 化学式: C₉H₁₂N₂O₅S
• 分子量: 260.27
• InChiKey: GJTBSTBJLVYKAU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  134
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• Substituted nucleotides and nucleosides for treating viral infections
  申请人：Emory University

  公开号：US11166973B2

  公开（公告）日：2021-11-09

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating viral infections, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether. The nucleotide or nucleoside is defined by Formula Ia below:

  本公开涉及治疗病毒感染的核苷酸和核苷治疗组合物和用途，其中核苷酸或核苷的碱基含有至少一种硫醇、硫酮或硫醚。核苷酸或核苷的定义如下式 Ia：
• NUCLEOTIDE AND NUCLEOSIDE COMPOSITIONS AND THEIR USES
  申请人：Emory University

  公开号：EP3043803B1

  公开（公告）日：2022-04-27
• COMPOSITIONS AND METHODS FOR THE IDENTIFICATION OF INHIBITORS OF RETROVIRAL INFECTION
  申请人：Guenther Richard H.

  公开号：US20100291032A1

  公开（公告）日：2010-11-18

  Methods of identifying inhibitors of retroviral propagation, tRNA used in the methods, and kits, including the tRNA, which can be used in the methods, are disclosed. Methods of treating or preventing retroviral infections by administering an effective amount of the inhibitors, and pharmaceutical compositions including the inhibitors, are also disclosed. The methods involve forming a mixture comprising a linear sequence of a tRNA anticodon stem loop fragment that is not capable of forming a stem-loop, a target nucleic acid molecule capable of binding to the tRNA anticodon stem loop fragment, and a test compound. The mixture is incubated under conditions that allow binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule in the absence of the test compound. Assays can then be performed that detect whether or not the test compound inhibits the binding of the tRNA anticodon stem loop fragment and the target nucleic acid molecule.
• Nucleotide and Nucleoside Therapeutic Compositions and Uses Related Thereto
  申请人：Emory University

  公开号：US20190298750A1

  公开（公告）日：2019-10-03

  This disclosure relates to nucleotide and nucleoside therapeutic compositions and uses in treating infectious diseases, viral infections, and cancer, where the base of the nucleotide or nucleoside contains at least one thiol, thione or thioether.
• US9173886B2
  申请人：——

  公开号：US9173886B2

  公开（公告）日：2015-11-03