3-tert-butoxycarbonyl-amino-3,4-dihydro-1H-naphthalen-2-one | 132499-45-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 3-tert-butoxycarbonyl-amino-3,4-dihydro-1H-naphthalen-2-one
• 英文别名: (+)-3-Tert-butoxycarbonylamino-3,4-dihydro-2(1H)-naphthalenone；3-Tert-butoxycarbonylamino-3,4-dihydro-2(1H)-naphthalenone；tert-butyl N-(3-oxo-2,4-dihydro-1H-naphthalen-2-yl)carbamate
• CAS: 132499-45-7
• 化学式: C₁₅H₁₉NO₃
• 分子量: 261.321
• InChiKey: VIPKVDHZXNPDEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-tert-butoxycarbonyl-amino-3,4-dihydro-1H-naphthalen-2-one 生成 3-Amino-2-tetralone hydrochloride
  参考文献：
  名称：

  Novel tetralin derivatives

  摘要：

  本发明涉及新型四氢萘衍生物，涉及其制备过程，涉及其作为氨基肽酶抑制剂的用途，以及涉及其作为免疫调节剂和镇痛剂的最终应用。

  公开号：

  US05041673A1
• 作为产物：
  描述：

  1,4-二羟基萘 以 甲醇 、 ammonium hydroxide 、 正己烷 、 二氯甲烷 、 氯仿 、 乙腈 为溶剂， 生成 3-tert-butoxycarbonyl-amino-3,4-dihydro-1H-naphthalen-2-one
  参考文献：
  名称：

  Novel tetralin derivatives

  摘要：

  本发明涉及新型四氢萘衍生物，涉及其制备过程，涉及其作为氨基肽酶抑制剂的用途，以及涉及其作为免疫调节剂和镇痛剂的最终应用。

  公开号：

  US05041673A1

文献信息

• Method of using certain tetralin derivatives to produce analgesic relief
  申请人：Merrell Dow Pharmaceuticals Inc.

  公开号：US05106861A1

  公开（公告）日：1992-04-21

  This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as amino-peptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.

  本发明涉及四氢萘的新衍生物，以及它们的制备过程，它们作为氨肽酶抑制剂的用途，以及它们的最终应用作为免疫调节剂和镇痛剂。
• Tetralin derivatives
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0378456A1

  公开（公告）日：1990-07-18

  This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as amino­peptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.

  本发明涉及四氢萘的新型衍生物、四氢萘的制备工艺、四氢萘作为氨肽酶抑制剂的用途以及四氢萘作为免疫调节剂和镇痛剂的最终用途。
• Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors
  作者：Sébastien Albrecht、Albert Defoin、Emmanuel Salomon、Céline Tarnus、Anders Wetterholm、Jasper Z. Haeggström

  DOI：10.1016/j.bmc.2006.06.050

  日期：2006.11

  Racemic derivatives of 3-amino-2-tetralone were synthesised and evaluated for their ability to inhibit metallo-aminopeptidase activities. New compounds substituted in position 2 by methyl ketone, substituted oximes or hydroxamic acids as well as heterocyclic derivatives were evaluated against representative members of zinc-dependent aminopeptidases: leucine aminopeptidase (E.C. 3.4.11.1), aminopeptidase-N(E.C. 3.4.11.2), Aeronumas proteolytica aminopeptidase (E.C. 3.4.11.10), and the aminopeptidase activity of leukotriene A(4) hydrolase (E.C. 3.3.2.6). Several compounds showed K-i values in the low micromolar range against the 'one-zinc' aminopeptidases, while most of them were rather poor inhibitors of the 'two-zinc' enzymes. This interesting selectivity profile may guide the design of new, specific inhibitors of target mammalian aminopeptidases with one active site zinc. (c) 2006 Elsevier Ltd. All rights reserved.
• US5041673A
  申请人：——

  公开号：US5041673A

  公开（公告）日：1991-08-20
• US5106861A
  申请人：——

  公开号：US5106861A

  公开（公告）日：1992-04-21