24-methylene-cholest-4-ene-3-one | 55688-44-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 24-methylene-cholest-4-ene-3-one
• 英文别名: 24-methylcholesta-4,24(28)-dien-3-one；ergosta-4,24(28)-diene-3-one；ergosta-4,24(28)-dien-3-one；ergost-4,24(28)-diene-3-one；(8S,9S,10R,13R,14S,17R)-10,13-dimethyl-17-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one
• CAS: 55688-44-3
• 化学式: C₂₈H₄₄O
• 分子量: 396.657
• InChiKey: JRMPVNVOLQJLJX-QVMRCSLBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  (3S,8S,9S,10R,13R,14S,17R)-17-((R)-1,5-Dimethyl-4-methylene-hexyl)-10,13-dimethyl-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 在 环己酮 、 aluminum isopropoxide 作用下， 以 甲苯 为溶剂， 生成 24-methylene-cholest-4-ene-3-one
  参考文献：
  名称：

  海绵类固醇

  摘要：

  海绵Stelleta clarella Tethya aurantia，Lissodendoryx noxiosa，Haliclona permollis和Haliclona sp.。被检查类固醇。所有海绵含有的C 27 -C 29，Δ 5，单和二不饱和甾醇。此外，海绵Tethya aurantia包含Z-24-亚丙基-胆甾-5- en- 3β -ol（19）和胆甾醇的5α，8α-过氧化物-5,7-二烯-3β-ol，麦角甾醇，麦角甾醇- 5,7,24（28） -三烯- 3β -醇和24ξ -乙基-胆- 5,7 -二烯- 3β -醇（29，30，31和32）。海绵Stelleta clarella还包含24-nor-cholesta-4,22-dien-3-一（21），cholesta-4,22-dien-3-一（22），24ξ-甲基-cholesta-4,22-dien-3-一（24），ergosta-4

  DOI：

  10.1016/s0040-4020(01)97391-0

文献信息

• Isolierung von 24-Methylencholesterin aus Königinnen und Arbeiterinnen der Honigbiene (<i>Apis mellifica</i>L.)
  作者：M. Barbier、O. Schindler

  DOI：10.1002/hlca.19590420631

  日期：——

  Aus den pentanlöslichen Neutralstoffen von t-Butanol-Extrakten von Königinnen und Arbeiterinnen der Honigbiene (Apis mellifica L.) konnte 24-Methylencholesterin isoliert werden.

  从蜜蜂（Apis mellifica L.）的皇后和工人的叔丁醇提取物中戊烷可溶的中性物质中分离出24-甲基胆固醇。
• Antileishmanial compositions and methods of use
  申请人：Ohio State Innovation Foundation

  公开号：US10174072B2

  公开（公告）日：2019-01-08

  In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from Pentalinon andrieuxii. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  一方面，本发明涉及治疗寄生虫病（例如利什曼病）的方法和组合物。在另一个方面，本发明方法和组合物的化合物是从 Pentalinon andrieuxii 中分离出来的。本摘要旨在作为一种扫描工具，用于在特定技术领域进行搜索，并非对本发明的限制。
• ANTILEISHMANIAL COMPOSITIONS AND METHODS OF USE
  申请人：Satoskar Abhay R.

  公开号：US20140287030A1

  公开（公告）日：2014-09-25

  In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from Pentalinon andrieuxii . This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• STEROLS AS NOVEL IMMUNOMODULATORY AGENTS AND THEIR USE AS VACCINE ADJUVANTS
  申请人：Ohio State Innovation Foundation

  公开号：US20200197514A1

  公开（公告）日：2020-06-25

  Disclosed herein are methods of using immunomodulatory sterols as vaccine adjuvants. Accordingly, certain embodiments relates to pharmaceutical compositions containing at least one antigen and at least one immunomodulatory sterol; and, methods of inducing an immunomodulatory response in a patient by administering an immunomodulatory-effective amount of at least one immunomodulatory sterol.
• [EN] ANTILEISHMANIAL COMPOSITIONS AND METHODS OF USE<br/>[FR] COMPOSITIONS ANTILESHMANIENNES ET SES MÉTHODES D'UTILISATION
  申请人：UNIV OHIO STATE

  公开号：WO2012145734A1

  公开（公告）日：2012-10-26

  In one aspect, the invention relates methods and compositions for treating parasitic diseases, for example, leishmaniasis. In a further aspect, the compounds of the methods and compositions are isolated from Pentalinon andrieuxii. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.