N-丙基萘-2-胺 | 36190-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: N-丙基萘-2-胺
• 英文名称: N-propyl-2-aminonaphthalene
• 英文别名: N-propyl-2-naphthylamine；[2]naphthyl-propyl-amine；Propyl-β-naphthylamin；[2]Naphthyl-propyl-amin；2-n-Propylaminonaphthalin；N-Propyl-2-naphthalenamine；N-propylnaphthalen-2-amine
• CAS: 36190-75-7
• 化学式: C₁₃H₁₅N
• 分子量: 185.269
• InChiKey: KEFWNHAJKUZOOG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

安全信息

• 海关编码：
  2921450090

反应信息

• 作为反应物：
  描述：

  N-丙基萘-2-胺 在 rhodium contaminated with carbon 、 三氟乙酸 作用下， 以 三氟乙酸 为溶剂， 反应 2.0h， 以83%的产率得到N,N'-dipropyl-1,1'-binaphthalen-2,2'-diamine
  参考文献：
  名称：

  Aerobic Oxidative Homocoupling of Aryl Amines Using Heterogeneous Rhodium Catalysts

  摘要：

  The first heterogeneous catalyzed oxidative coupling of aryl amines is reported. Aryl amines were dimerized at room temperature under air using a heterogeneous Rh/C catalyst in the presence of acids. By choosing a suitable acidic solvent, biaryl compounds and carbazoles were selectively prepared in good yields. This reaction is operationally simple and provides an efficient synthetic methodology for the preparation of biaryl diamines via oxidative C-H activation.

  DOI：

  10.1021/ol502197p
• 作为产物：
  描述：

  2-萘胺 在 水 作用下， 生成 N-丙基萘-2-胺
  参考文献：
  名称：

  Bischoff; Mintz, Chemische Berichte, 1892, vol. 25, p. 2324

  摘要：

  DOI：

文献信息

• Copper catalyzed coupling of aryl chlorides, bromides and iodides with amines and amides
  作者：Hanhui Xu、Christian Wolf

  DOI：10.1039/b823407h

  日期：——

  A copper(I) catalyzed procedure for carbon–nitrogen bond formation utilizing aryl halides and either amines, including amino acids and diphenylamine, or aliphatic and aromatic amides is described.

  描述了一种铜(I)催化的碳-氮键形成方法，该方法利用了芳基卤化物和胺类（包括氨基酸和二苯胺）或脂肪族和芳香族酰胺。
• PHEN-NAPHTHALENE AND PHEN-QUINOLINE DERIVATIVES AND THEIR USE FOR BINDING AND IMAGING AMYLOID PLAQUES
  申请人：Kung Hank F.

  公开号：US20100215579A1

  公开（公告）日：2010-08-26

  This invention relates to methods of imaging amyloid deposits, radiolabeled compounds, and methods of making radiolabeled compounds useful in imaging amyloid deposits. This invention also relates to compounds and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits and methods of delivering therapeutic agents to amyloid deposits.

  本发明涉及成像淀粉样沉积物的方法、放射性标记化合物以及用于成像淀粉样沉积物的放射性标记化合物的制备方法。本发明还涉及化合物和制备化合物的方法，用于抑制淀粉样蛋白聚集形成淀粉样沉积物以及将治疗剂传递到淀粉样沉积物中的方法。
• Saturated heterocyclic carboxamide derivatives
  申请人：YAMANOUCHI PHARMACEUTICAL CO. LTD.

  公开号：EP0279681A2

  公开（公告）日：1988-08-24

  A saturated heterocyclic carboxamide derivative of the following general formula (I) and salts thereof which have platelet activating factor (PAF) antagonizing activity.

  具有血小板活化因子（PAF）拮抗活性的下式（I）饱和杂环羧酰胺衍生物及其盐类。
• N-SUBSTITUTED 2,5-DIOXO-AZOLINE COMPOUNDS FOR USE IN THE TREATMENT OF CANCER
  申请人：CanBas Co., Ltd.

  公开号：EP3567035A1

  公开（公告）日：2019-11-13

  Novel substituted azole diones are provided that kill cells, suppress cell proliferation, suppress cell growth, abrogate the cell cycle G2 checkpoint and/or cause adaptation to G2 cell cycle arrest. Methods of making and using the invention compounds are provided. The invention provides substituted azole diones to treat cell proliferation disorders. The invention includes the use of substituted azole diones to selectively kill or suppress cancer cells without additional anti-cancer treatment. The invention includes the use of cell cycle G2-checkpoint-abrogating substituted azole diones to selectively sensitize cancer cells to DNA damaging reagents, treatments and/or other types of anti-cancer reagents.

  本发明提供了新型取代唑二酮类化合物，可杀死细胞、抑制细胞增殖、抑制细胞生长、减弱细胞周期 G2 检查点和/或导致细胞周期 G2 停滞。本发明还提供了制造和使用本发明化合物的方法。本发明提供了用于治疗细胞增殖障碍的取代唑二酮类化合物。本发明包括使用取代的唑二酮选择性地杀死或抑制癌细胞，而无需额外的抗癌治疗。本发明包括使用细胞周期G2-检查点抑制取代的唑二酮类化合物选择性地使癌细胞对DNA损伤试剂、治疗和/或其它类型的抗癌试剂敏感。
• MIXED ETHYLENE ALPHA OLEFIN COPOLYMER MULTIFUNCTIONAL VISCOSITY MODIFIERS USEFUL IN LUBE OIL COMPOSITIONS
  申请人：EXXON CHEMICAL PATENTS INC.

  公开号：EP0673407A1

  公开（公告）日：1995-09-27