N¹-methyladenine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 咪唑并嘧啶类
• 英文名称: N¹-methyladenine
• 英文别名: 1,9-dimethyl-adenine cation；1,9-Dimethylpurin-1-ium-6-amine
• 化学式: C₇H₁₀N₅
• 分子量: 164.19
• InChiKey: FYKDNUMFZTYMLQ-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  60.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N¹-methyladenine 在 hydroxide 作用下， 生成 5-Formylamino-1,N-dimethyl-1H-imidazole-4-carboxamidine
  参考文献：
  名称：

  Purines. XLIV. A kinetic study of the dimroth rearrangement of the marine sponge purine 1,9-dimethyl-8-oxoadenine and related compounds.

  摘要：

  在40°C、pH值不同、离子强度为1.0的H2O中，测量了海洋海绵基质1, 9-二甲基-8-氧代腺嘌呤（1）和1, 9-二甲基腺嘌呤（6a）以及8-溴-1, 9-二甲基腺嘌呤（6b）等相关化合物的迪姆罗斯重排反应速率。在所有情况下，氢氧根离子对2位基质质子化物种的侵袭速度比中性物种快100-1400倍。在质子化物种的反应中，发生迪姆罗斯重排的相对难易程度依次为6b>6a>1。中性物种的反应顺序也与此相同。

  DOI：

  10.1248/cpb.38.2591

文献信息

• PROTEIN DEMETHYLASES COMPRISING A JMJC DOMAIN
  申请人：Zhang Yi

  公开号：US20090203057A1

  公开（公告）日：2009-08-13

  Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.
• Nucleosides and Oligonucleotides for Studies on Reversal of Cytotoxic and Mutagenic Damage of DNA and as Diagnostics Tools
  申请人：ChemGenes Corporation

  公开号：US20140350234A1

  公开（公告）日：2014-11-27

  The present invention is directed to n-alkylated synthetic nucleosides of high regiospecific purity and oligonucleotides that can be utilized for studies on reversal of cytotoxic and mutagenic DNA damage, and as diagnostic tools.
• Protein Demethylases Comprising a JMJC Domain
  申请人：The University of North Carolina at Chapel Hill

  公开号：US20160244802A1

  公开（公告）日：2016-08-25

  Post-translational modification, including protein methylation, plays an important role in regulating protein function. The present invention provides a novel assay for evaluating demethylase activity and the discovery of a family of protein demethylases comprising a novel demethylase motif.
• US8785619B1
  申请人：——

  公开号：US8785619B1

  公开（公告）日：2014-07-22
• US9718855B2
  申请人：——

  公开号：US9718855B2

  公开（公告）日：2017-08-01