1,3-dibenzyl-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one | 832676-81-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 1,3-dibenzyl-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one
• 英文别名: Imidazo[2,1-b]quinazolin-2(3H)-one, 1,5-dihydro-1,3-bis(phenylmethyl)-；1,3-dibenzyl-3,5-dihydroimidazo[2,1-b]quinazolin-2-one
• CAS: 832676-81-0
• 化学式: C₂₄H₂₁N₃O
• 分子量: 367.45
• InChiKey: JNUFSYMQUWVTEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  35.9
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-芴甲氧羰基-DL-苯丙氨酸 、 异硫氰酸苯甲酯 、 邻硝基苯甲醛 以55%的产率得到1,3-dibenzyl-1,5-dihydro-imidazo[2,1-b]quinazolin-2-one
  参考文献：
  名称：

  Solid-phase synthesis of imidazoquinazolinone derivatives with three-point diversity

  摘要：

  A novel imidazoquinazolinone-based tricyclic structure with three-point diversity has been synthesized using solid-phase methodology. The compounds were obtained by treating the amino group of polymer-linked amino acids with 2-nitrobenzaldehyde followed by reduction of the nitro group to an amine. Derivatization of amine with isothiocyanates and cyclization of the resulting thioureas with DIC followed by acidolytic cleavage yielded the desired imidazoquinazolinone based compounds in high purity and moderate to high yield. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2004.10.090

文献信息

• Solid-phase synthesis of imidazoquinazolinone derivatives with three-point diversity
  作者：Amit P. Kesarwani、Rajesh K. Grover、Raja Roy、Bijoy Kundu

  DOI：10.1016/j.tet.2004.10.090

  日期：2005.1

  A novel imidazoquinazolinone-based tricyclic structure with three-point diversity has been synthesized using solid-phase methodology. The compounds were obtained by treating the amino group of polymer-linked amino acids with 2-nitrobenzaldehyde followed by reduction of the nitro group to an amine. Derivatization of amine with isothiocyanates and cyclization of the resulting thioureas with DIC followed by acidolytic cleavage yielded the desired imidazoquinazolinone based compounds in high purity and moderate to high yield. (C) 2004 Elsevier Ltd. All rights reserved.