4-(benzenesulfonyl)isoquinoline-N-oxide | 1426249-92-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: 4-(benzenesulfonyl)isoquinoline-N-oxide
• 英文别名: 4-(Benzenesulfonyl)-2-oxidoisoquinolin-2-ium；4-(benzenesulfonyl)-2-oxidoisoquinolin-2-ium
• CAS: 1426249-92-4
• 化学式: C₁₅H₁₁NO₃S
• 分子量: 285.323
• InChiKey: FYOIUYBGSPKBOQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  异喹啉-N-氧化物 、 4-氟苯磺酰氯 在 copper(l) iodide 、 potassium carbonate 作用下， 反应 24.0h， 以88%的产率得到4-(benzenesulfonyl)isoquinoline-N-oxide
  参考文献：
  名称：

  Sulfonylation of Quinoline N-Oxides with Aryl Sulfonyl Chlorides via Copper-Catalyzed C–H Bonds Activation

  摘要：

  An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.

  DOI：

  10.1021/ol400178k

文献信息

• Sulfonylation of Quinoline <i>N</i>-Oxides with Aryl Sulfonyl Chlorides via Copper-Catalyzed C–H Bonds Activation
  作者：Zhiyong Wu、Hongyu Song、Xiuling Cui、Chao Pi、Weiwei Du、Yangjie Wu

  DOI：10.1021/ol400178k

  日期：2013.3.15

  An efficient and concise one-pot protocol to synthesize sulfonylated quinoline N-oxides via copper-catalyzed C H bond activation has been developed. Commercially available and less expensive aryl sulfonyl chlorides were used as the sulfonylation reagents. Various 2-aryl sulfonyl quinolines were obtained in up to 91% yields in chemo- and regioselective manners.