(+)-8-Hydroxymanzamine J

• 分子结构分类: 有机化合物 - 生物碱及其衍生物 - 哈马拉生物碱
• 英文名称: (+)-8-Hydroxymanzamine J
• 英文别名: (1R,2R,5Z,12R,13S,16Z)-25-(8-hydroxy-9H-pyrido[3,4-b]indol-1-yl)-11,22-diazatetracyclo[11.11.2.12,22.02,12]heptacosa-5,16,25-trien-13-ol
• 化学式: C₃₆H₄₆N₄O₂
• 分子量: 566.8
• InChiKey: BLGVMYSFSXUVEE-QSJPHVJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  42
• 可旋转键数：
  1
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  84.4
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Methods of treating disease through the administration of a manzamine analog or derivative
  申请人：Hamann T. Mark

  公开号：US20050085554A1

  公开（公告）日：2005-04-21

  A method of treating cancer, inflammatory disease or an infectious disease or condition in a subject in need of such treatment is disclosed. The method comprises administering to a subject an effective amount of a manzamine, or a rationally modified manzamine derivative or analog or an optical isomer or racemate or tautomer thereof or a pharmaceutically acceptable salt or prodrug thereof generated through optimized fermentation of a Micromonospora sp., extraction from sponges and then modified through semisynthesis.

  本方法揭示了一种治疗癌症、炎症性疾病或感染性疾病或状况的方法，适用于需要此类治疗的受试者。该方法包括向受试者施用有效量的曼莎明、或经合理改造的曼莎明衍生物或类似物或其光学异构体或消旋体或亚式异构体或在aMicromonosporasp.经过优化发酵生成的药学上可接受的盐或前药，然后通过半合成进行修改。
• [EN] METHODS OF TREATING DISEASE THROUGH THE ADMINISTRATION OF A MANZAMINE ANALOG OR DERIVATIVE<br/>[FR] METHODES DE TRAITEMENT DES MALADIES PAR ADMINISTRATION D'UN ANALOGUE OU D'UN DERIVE DE MANZAMINE
  申请人：UNIV MISSISSIPPI

  公开号：WO2005084157A2

  公开（公告）日：2005-09-15

  A method of treating cancer, inflammatory disease or an infectious disease or condition in a subject in need of such treatment is disclosed. The method comprises administering to a subject an effective amount of a manzamine, or a rationally modified manzamine derivative or analog or an optical isomer or racemate or tautomer thereof or a pharmaceutically acceptable salt or prodrug thereof generated through optimized fermentation of a Micromonospora sp., extraction from sponges and then modified through semisynthesis.