1-Palmitoyl-2-arachidonyl-phosphatidylcholine

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 甘油磷脂
• 英文名称: 1-Palmitoyl-2-arachidonyl-phosphatidylcholine
• 英文别名: 2-[[(2R)-3-hexadecanoyloxy-2-[(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoyl]oxypropoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium
• 化学式: C44H81NO8P+
• 分子量: 783.1
• InChiKey: IIZPXYDJLKNOIY-JXPKJXOSSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  12.7
• 重原子数：
  54
• 可旋转键数：
  40
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  8

文献信息

• Methods for the treatment of peri-implantitis
  申请人：POLYPID LTD.

  公开号：US10758639B2

  公开（公告）日：2020-09-01

  The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and prolonged release of at least one pharmaceutically active agent at the bone loss site.

  本发明涉及治疗种植体周围疾病的药物组合物和方法，特别是以支撑种植体的牙槽骨嵴破坏为特征的种植体周围疾病。具体地说，该方法包括以下步骤：在显示骨嵴吸收的种植体周围骨上施用药物组合物，该药物组合物包括涂有基质组合物的生物相容性骨增量材料，该基质组合物可在骨丢失部位提供至少一种药物活性剂的局部控制和长期释放。
• COMPOSITIONS AND METHODS FOR THE TREATMENT AND PROPHYLAXIS OF SURGICAL SITE INFECTIONS
  申请人：Polypid Ltd.

  公开号：EP3200748B1

  公开（公告）日：2021-10-27
• COMPOSITIONS FOR THE TREATMENT OF PERI-IMPLANTITIS
  申请人：Polypid Ltd.

  公开号：EP3200749B1

  公开（公告）日：2020-09-02
• METHODS FOR THE TREATMENT OF PERI-IMPLANTITIS
  申请人：POLYPID LTD.

  公开号：US20170246342A1

  公开（公告）日：2017-08-31

  The present invention relates to pharmaceutical compositions and methods for the treatment of peri-implant diseases, in particular peri-implant disease characterized by the destruction of the crest of the alveolar bone supporting the implant. Specifically, the method comprising the step of applying to a peri-implant bone displaying crestal resorption a 5 pharmaceutical composition comprising biocompatible bone augmentation material coated with a matrix composition which provides local controlled and pro longed release of at least one pharmaceutically active agent at the bone loss site.
• PHOSPHOLIPID COMPOSITIONS
  申请人：MACHAVERT PHARMACEUTICALS LLC

  公开号：US20180028545A1

  公开（公告）日：2018-02-01

  Compositions involving a modified egg yolk extract for use as an effective anti-cancer agent are described. The modified egg yolk extract involves specific fractions of phosphatidylcholines and sphingomyelins modified and produced from a chemical synthesis applied to the extract that produce a beneficial effect on the inhibition of cancerous cell growth. Methods of administering these compositions are also described.