1alpha,11alpha,25-trihydroxyvitamin D3/1alpha,11alpha,25-trihydroxycholecalciferol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1alpha,11alpha,25-trihydroxyvitamin D3/1alpha,11alpha,25-trihydroxycholecalciferol
• 英文别名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,6S,7aR)-6-hydroxy-1-[(2R)-6-hydroxy-6-methylheptan-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• 化学式: C₂₇H₄₄O₄
• 分子量: 432.644
• InChiKey: UZTZPZGEOANDJC-LJMJVLGYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  31
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  [3S-(1Z,3a,5b)]-[2-[3,5-二[(叔丁基)二甲基硅氧基]-2-亚甲基环己亚基]乙基]二苯基氧化膦 、 、 Toluene-4-sulfonic acid (S)-2-((1R,3aR,6R,7aR)-6-hydroxy-7a-methyl-4-oxo-octahydro-inden-1-yl)-propyl ester 生成 1alpha,11alpha,25-trihydroxyvitamin D3/1alpha,11alpha,25-trihydroxycholecalciferol
  参考文献：
  名称：

  An Efficient Solid-Phase Synthesis of the Vitamin D₃ System

  摘要：

  DOI：

  10.1021/ja990739c

文献信息

• METHODS AND ASSAYS FOR USE IN DIAGNOSIS OF LAMINITIS
  申请人：PEPSIS LIMITED

  公开号：US20210148933A1

  公开（公告）日：2021-05-20

  The invention concerns a method and assay for qualifying equine laminitis disease status in a subject by measuring specific biomarkers, comparing the level of said biomarker to a control level; and correlating the measurement with laminitis disease status, wherein a statistically relevant elevated level of said biomarker is present in said sample relative to said control level. The invention further relates to immuno-based methods and assays for detecting toxins relevant to laminitis and to the use of antibodies for assay and diagnostic purposes.